中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1181-1185.doi: 10.4103/1673-5374.162686

• 综述:退行性病与再生 •    下一篇

姜黄素和芹菜素:对抗阿尔茨海默病慢性神经炎症有希望

  

  • 收稿日期:2015-05-21 出版日期:2015-08-24 发布日期:2015-08-24

Curcumin and Apigenin – novel and promising therapeutics against chronic neuroinflammation in Alzheimer’s disease

Madhuri Venigalla1, Erika Gyengesi1, 3, Gerald Münch1, 2, 3, *   

  1. 1 Department of Pharmacology, School of Medicine, University of Western Sydney, Campbelltown, NSW, Australia
    2 National Institute of Complementary Medicine, University of Western Sydney, Penrith, NSW, Australia
    3 Molecular Medicine Research Group, University of Western Sydney, Penrith, NSW, Australia
  • Received:2015-05-21 Online:2015-08-24 Published:2015-08-24
  • Contact: Gerald Münch, Ph.D., g.muench@uws.edu.au.

摘要:

阿尔茨海默病是一种进行性神经退行性疾病,主要病理特征是淀粉样蛋白β沉积、神经原纤维缠结、星形胶质细胞和小神经胶质细胞增生,导致大脑的神经元功能障碍和丢失。目前治疗阿尔茨海默病的方法主要集中在增强胆碱能传输方面。然而,这些治疗方法只具有症候,对阿尔茨海默病患者来说还没有有治疗作用的修饰药物。该篇综述将介绍姜黄素和芹菜素的抗氧化、抗炎、抗淀粉样沉积、神经保护,以及增强认知的效应和其对阿尔茨海默病的潜在预防和治疗作用。我们建议这些化合物的治疗用途可能引导阿尔茨海默病的安全策略,并能够延缓阿尔茨海默病的发作或减慢其进展。对这些物质潜在作用的的继续研究是十分必要的,因为它们是有希望可能产生补救这种普遍疾病的化合物。

Abstract:

Alzheimer’s disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer’s disease primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for Alzheimer’s disease patients. This review will provide an overview of the proven antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of curcumin and apigenin and discuss the potential of these compounds for Alzheimer’s disease prevention and treatment. We suggest that these compounds might delay the onset of Alzheimer’s disease or slow down its progression, and they should enter clinical trials as soon as possible.

Key words: Alzheimer’s disease, neuroinflammation, anti-inflammatory drugs, plant secondary metabolites, reactive oxygen species