中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1201-1203.doi: 10.4103/1673-5374.162690

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

 生长激素的神经保护作用

  

  • 收稿日期:2015-05-20 出版日期:2015-08-24 发布日期:2015-08-24

The neuroprotective effects of human growth hormone as a potential treatment for amyotrophic lateral sclerosis

Jin-Young Chung, Jun-Sang Sunwoo, Min-Wook Kim, Manho Kim   

  1. Department of Veterinary Internal Medicine and Geriatrics, Kangwon National University, Gangwondo, South Korea(Chung JY)
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea (Sunwoo JS, Kim M)
    Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea (Kim MW)
    Institute of Catholic Integrative Medicine (ICIM), Incheon St. Mary’s Hospital, Incheon, South Korea (Kim MW)
    Protein Metabolism Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea (Kim M)
  • Received:2015-05-20 Online:2015-08-24 Published:2015-08-24
  • Contact: Manho Kim, M.D., Ph.D., kimmanho@snu.ac.kr.
  • Supported by:

    This work was supported by grants from the Korea Health 21 R & D Project (HI14C2348) and the National Research Foundation of Korea (NRF2014R1A2A1A11051520).

摘要:

生长激素(GH)是一种单链多肽,具有191个氨基酸,主要控制各种生理过程,例如生长和代谢。生长激素结合到靶细胞的细胞膜受体,如脂肪细胞和软骨细胞可直接刺激增殖。另外,生长激素可以通过肝脏和靶组织胰岛素样生长因子-1(IGF-1)的合成间接发挥作用。 IGF-1实际施加在一个大范围组织的生长促进作用,并导致骨和肌肉的生长。关于代谢调控,生长激素可促进蛋白质合成代谢,动员储存甘油三酯,肝葡萄糖生成和胰岛素抵抗。该观点文章描述了信号转导途径,大脑中的生理功能,重点是生长激素在肌萎缩性侧索硬化症中治疗潜力和治疗作用。

Abstract:

The Neuroprotective Effects of Growth Hormone Growth hormone (GH) is a single-chain polypeptide with 191 amino acids that mainly controls various physiologic processes such as growth and metabolism. GH binds to the membrane receptors of target cells such as adipocyte and chondrocyte, and directly stimulates proliferation. In addition, GH can act indirectly through the synthesis of insulin-like growth factor 1 (IGF-1) in the liver and target tissue. IGF-1 actually exerts growth promoting effects on a wide range of tissue, and leads to the bone and muscle growth. Regarding to the control of metabolism, GH promotes protein anabolism, mobilization of stored triglyceride, hepatic glucose production, and insulin resistance. This perspective wrote by Prof. Manho Kim's team (Seoul National University Hospital) describes the signal transduction pathway, physiological functions in the brain, and the neuroprotective effects of GH with focus on its therapeutic potential in amyotrophic lateral sclerosis (ALS).