中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1204-1205.doi: 10.4103/1673-5374.162692

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

血管干细胞环境:是神经祖细胞移植的路线图么?

  

  • 收稿日期:2015-05-25 出版日期:2015-08-24 发布日期:2015-08-24

The vascular stem cell niche: roadmap for transplanted neural progenitor cells during environmental enrichment?

Ben Waldau   

  1. Department of Neurosurgery, UC Davis Medical Center, 4860 Y Street, ACC 3740, Sacramento 95817, CA, USA
  • Received:2015-05-25 Online:2015-08-24 Published:2015-08-24
  • Contact: Waldau, M.D., ben.waldau@ucdmc.ucdavis.edu.
  • Supported by:

    This work was supported by the 2011 William P. Van Wagenen Award from the American Association of Neurological Surgeons (AANS) and basic institutional funding.

摘要:

进行脑部细胞移植入的挑战之一是移植后的存活率极低。移植物的存活可能会受到宿主对移植细胞的免疫应答、细胞移植过程中的剪切损伤或不适合移植细胞类型的微环境等影响。神经祖细胞对层粘连蛋白具有亲和力,其通常用于体外维持神经祖细胞的单层培养。神经祖细胞对层粘连蛋白的亲和力是基于高表达的α6β1整联,这是需要神经祖细胞与内皮细胞进行结合。我们观察到移植的神经祖细胞与血管干细胞小生境密切相关,并且响应于环境富集。因此,在人体中进行的神经祖细胞移植物的存活率可以通过物理,职业或语言治疗提高局部脑血流灌注,并有助于促进移植细胞目标地区所需的生存率。需要进一步的研究来研究移植齿状祖细胞与血管干细胞小生境和响应环境富集协会是否持续一段时间。

Abstract:

The vascular stem cell niche: roadmap for transplanted neural progenitor cells during environmental enrichment?
One of the challenges of cell transplantation into the brain is poor graft survival. Graft survival may be affected by an immunological response of the host towards transplanted cells, shear injury to cells during transplantation or an unsuitable micro-environment for the transplanted cell type. Prof. Ben Waldau (UC Davis Medical Center, USA) proposed that neural progenitor cells have an affinity to laminin, which is commonly used to maintain neural progenitorsas monolayer cultures in vitro. The affinity of neural progenitor cells to laminin is based on thehigh expression ofα6β1 integrin, which is required for binding of neural progenitors to endothelial cells. They observed that transplanted neural progenitor cells are closely associated with the vascular stem cell niche and responsive to environmental enrichment. Therefore, survival of neural progenitor cell grafts in humans may be enhanced by physical, occupational or speech therapy to increase regional brain perfusion and help promote survival of transplanted cells in desired target areas. Further research is needed to study whether the association of transplanted dentate progenitor cells with the vascular stem cell niche and the responsiveness to environmental enrichment persists over time.