中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1209-1210.doi: 10.4103/1673-5374.162693

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

泛素平衡:从神经干细胞分化到神经元发育

  

  • 出版日期:2015-08-24 发布日期:2015-08-24

Ubiquitin homeostasis: from neural stem cell differentiation to neuronal development

Han-Wook Ryu, Kwon-Yul Ryu   

  1. Department of Life Science, University of Seoul, Seoul 130-743, Republic of Korea
  • Online:2015-08-24 Published:2015-08-24
  • Contact: Kwon-Yul Ryu, Ph.D., kyryu@uos.ac.kr.
  • Supported by:

    This work was supported by a grant from the Korean Health Technology R &D Projects, Ministry of Health & Welfare, Republic of Korea (HI14C2300) to KYR.

摘要:

众所周知,泛素是施加在细胞内的不同信号功能,包括针对其底物蛋白酶体降解的真核蛋白质。根据我们最近的研究报告,我们推测,测量游离泛素细胞的水平将是最佳分化为神经元和神经元发育的必不可少的元素。 泛素可能是确定神经干细胞命运的关键蛋白质之一。因此,泛动态平衡应该被考虑到在神经干细胞移植中的得到最大限度的应用。因此,我们的研究代表了一种新的和普遍的治疗策略用以克服各种神经退行性疾病发展的一个里程碑。

Abstract:

Ubiquitin homeostasis: From neural stem cell differentiation to neuronal development Ubiquitin (Ub) is a well-known eukaryotic protein that exerts diverse signaling functions inside the cells, including targeting its substrates for proteasomal degradation. Based on Prof. Kwon-Yul Ryu et al.' (University of Seoul, Republic of Korea) recent reports, they speculate that measuring cellular levels of free Ub will be essential for the optimal differentiation of neural stem cells into neurons and for neuronal development. Ub may be one of the key proteins in determining the fate of neural stem cells. Thus, Ub homeostasis should be considered to maximize the efficacy of neural stem cell transplantation. Therefore, their research represents a milestone in the development of a novel and universal therapeutic strategy to overcome various neurodegenerative diseases.