中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1211-1213.doi: 10.4103/1673-5374.162696

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

内质网分子伴侣的神经保护潜能

  

  • 收稿日期:2015-06-27 出版日期:2015-08-24 发布日期:2015-08-24

The neuroprotective potential of endoplasmic reticulum chaperones

Todd McLaughlin, Sarah X. Zhang   

  1. Departments of Ophthalmology and Biochemistry, Ross Eye Institute, University at Buffalo, State University of New York, Buffalo, NY, USA; SUNY Eye Institute, State University of New York, Buffalo, NY, USA
  • Received:2015-06-27 Online:2015-08-24 Published:2015-08-24
  • Contact: Sarah X. Zhang, M.D., xzhang38@buffalo.edu.
  • Supported by:

    This work is supported, in part, by NIH/NEI grants EY019949 and EY025061, American Diabetes Association Research Grant #7-11-BS-182, and an Unrestricted Grant to the Department of Ophthalmology, SUNY-Buffalo, from Research to Prevent Blindness.

摘要:

 

分子伴侣和未折叠蛋白的处理途径,有令人兴奋的作为细胞级神经保护剂用于多种神经变性疾病的治疗潜力。此外,内质网分子伴侣通过自分泌,旁分泌和内分泌调节信号来调节神经营养因子的产生和体内平衡上的重要作用有待研究。此外,内质网伴侣蛋白的调节在视网膜神经元的发展和再生以及其他神经系统也是一个有前景的未来研究领域。总之,深入了解的功能,特别是神经保护潜能,健康的和紧张的神经组织内质网分子伴侣可以提供管理多种类型的疾病并保持长效的一个有趣的方法。

Abstract:

 The molecular chaperones and the manipulation of the UPR pathways have exciting therapeutic potential as neuroprotectants at the cellular level for a variety of neurodegenerative diseases. Additionally, the importance of endoplasmic reticulum chaperones in regulating the production and homeostasis of neurotrophic factors through autocrine, paracrine, and endocrine signaling is worth pursuing. Furthermore, the implications of ER chaperone manipulation in the development and regeneration of neurons in the retina as well as other neural systems is potentially a very promising area for future study. All in all, in-depth understanding of the functions, in particular the neuroprotective potential, of ER chaperones in healthy and stressed neural tissues may provide an intriguing approach in managing multiple disease types to preserve long-term functionality.