中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1221-1222.doi: 10.4103/1673-5374.162748

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

(S)-3,5-二羟苯甘氨酸预处理对缺血性脑卒中的神经保护

  

  • 收稿日期:2015-07-09 出版日期:2015-08-24 发布日期:2015-08-24

The neuroprotective effects of (S)-3,5-dihydroxyphenylglycine preconditioning in middle cerebral artery occluded rats: a perspective as a contrivance for stroke

Nik Nasihah Nik Ramli, Rosfaiizah Siran   

  1. Faculty of Medicine, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia
  • Received:2015-07-09 Online:2015-08-24 Published:2015-08-24
  • Contact: Rosfaiizah Siran, Ph.D., iisturidza@yahoo.com.

摘要:

由于神经元的特性,卒中的损伤是不可逆的,缺血预处理不可能对缺血性中风的患者有所作用,但是,预处理是一个有吸引力的途径,其中易感的患者的缺血性脑损伤,如动脉内膜切除术和脑动脉瘤手术的风险较高的外科手术。我们表明,低剂量(S)-3,5-DHPG的预处理表现出可预防急性缺血性中风大鼠缺血的发作。因此,(S)-3,5-二羟苯甘氨酸的预处理作用机制的理解是研究对大脑中动脉缺血损伤的神经保护的一个关键点。

Abstract:

Due to the nature of neuron which is irreversible to damage, ischemic preconditioning is unlikely to give any benefit to ischemic stroke patients. However, preconditioning is an appealing avenue for surgical procedures which predisposed the patients with higher risk of ischemic brain injury such as endarterectomy and cerebral aneurysm surgery. We demonstrated that preconditioning with lower doses of (S)-3,5-DHPG showed to be protective against subsequent ischemic insult in the acute ischemic stroke rats. Therefore, understanding of mechanisms underlying the preconditioning effect of (S)-3,5-DHPG is a critical point of salvation in this area.