中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1237-1238.doi: 10.4103/1673-5374.162753

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

氨酰tRNA合成酶与周围神经变性及再生的关系

  

  • 收稿日期:2015-07-14 出版日期:2015-08-24 发布日期:2015-08-24

Aminoacyl tRNA synthetases and their relationships with peripheral nerve degeneration and regeneration

Junyang Jung   

  1. Department of Anatomy and Neurobiology, School of Medicine,
    Biomedical Science Institution, Kyung Hee University, Seoul, Republic of Korea
  • Received:2015-07-14 Online:2015-08-24 Published:2015-08-24
  • Contact: Junyang Jung, M.D., Ph.D., jjung@khu.ac.kr.
  • Supported by:

    This work was supported by a grant from the Kyung Hee University in 2013 (KHU20130548).

摘要:

作者所在研究小组初步结果表明氨酰-tRNA合成酶对周围神经变性和雪旺氏细胞再生的影响。目前,作者的研究主要集中于神经变性和再生过程中调查个别氨酰-tRNA合成酶在雪旺氏细胞中的作用。然而,如果开发新的治疗周围脱髓鞘疾病和退行性神经疾病策略,需要进行更多的实验研究。这些研究应着眼于确定哪些特定的氨酰-tRNA合成酶是周围神经变性和再生的必不可少的要素。

Abstract:

Following damage resulting from mechanical injury, viral infection, or autoimmunity, peripheral nerves degenerate and a variety of complications, including sensory loss, muscular paralysis, skin thinning, and a loss of tendon reflexes, can manifest. If these complications persist, they can cause a number of debilitating personal and/or social problems. For example, Guillain-Barre syndrome is induced by the degradation of myelin sheaths, and if the symptoms are not controlled the disease can be life-threatening due to the demyelination of respiratory muscle nerves. To date, effective treatment strategies that can inhibit the demyelination of peripheral nerves in the early stages of disease have yet to be developed. Thus, as with severe cases of Guillain-Barre syndrome, devices that alleviate the symptoms of respiratory muscular paralysis, including breathing machines, must be utilized until a cure can be developed.