中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1343-1344.doi: 10.4103/1673-5374.162950

• 其它 • 上一篇    

唾液酸神经节苷脂的神经保护作用

  

  • 收稿日期:2015-07-23 出版日期:2015-08-24 发布日期:2015-08-24
  • 基金资助:

    国家自然科学基金面上项目,项目批准号81373095

Neuroprotective effects of monosialotetrahexosylganglioside

Ai-ping Xi, Zhong-xin Xu, Feng-li Liu, Yan-li Xu   

  1. The Affiliated Hospital of Hebei University of Engineering, Handan, Hebei Province, China (Xi AP)
    School of Medicine, Hebei University of Engineering, Handan, Hebei Province, China (Xu ZX, Liu FL, Xu YL)
  • Received:2015-07-23 Online:2015-08-24 Published:2015-08-24
  • Contact: Yan-li Xu, Ph.D., xuyanli@vip.sina.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (General Program), No. 81373095.

摘要:

神经节苷脂是一类含唾液酸的糖鞘脂,与细胞间粘附及信号传导有着密切的联系。尤其是单唾液酸四已糖神经节苷脂在神经损伤后修复与再生中起着重要的作用。文章对唾液酸神经节苷脂的神经保护作用进行了初步分析,相信随着基础研究的深入,神经节苷脂发挥神经保护作用的分子机制将会得到进一步阐明,为临床研究提供更坚实的基础;同时,通过合理的设计研究进行临床随机对照试验,将为神经节苷脂应用于临床治疗开辟新的前景。

Abstract:

Monosialotetrahexosylganglioside (GM1) is a type of glycosphingolipid containing sialic acid and closely related to cell-cell recognition, adhesion and signal conduction. GM1 is mainly composed of ceramide and oligosaccharide chains, and it is the only ganglioside that can permeate the blood-brain barrier. The present review analyzed the neuroprotective effects of GM1. With further, in-depth study, the molecular mechanisms underlying the neuroprotective effects of ganglioside can be clarified and provide a solid foundation for clinical research. Moreover, well-designed, randomized controlled trials will open up new prospects for the clinical use of ganglioside.