中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (10): 1533-1536.doi: 10.4103/1673-5374.165213

• 综述:脊髓损伤修复保护与再生 •    下一篇

脊髓损伤后女性更具有神经保护优势? 

  

  • 收稿日期:2015-07-25 出版日期:2015-10-28 发布日期:2015-10-28
  • 基金资助:

    该研究得到CDMRP SCIRP(W81XWH-10-1-0793),迈阿密瘫痪治疗项目和Buoniconti基金资助。

Does being female provide a neuroprotective advantage following spinal cord injury?

Jeffrey P. Datto1, Jackie Yang1, W. Dalton Dietrich1, 2, 3, 4, 5, 6, Damien D. Pearse1, 2, 5, 6, *   

  1. 1 The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA
    2 The Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    3 The Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
    4 The Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL, USA
    5 The Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL, USA
    6 The Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA
  • Received:2015-07-25 Online:2015-10-28 Published:2015-10-28
  • Contact: Damien D. Pearse, Ph.D.,DPearse@med.miami.edu.
  • Supported by:

    Research was supported by CDMRP SCIRP Award No. W81XWH-10-1-0793, The Miami Project to Cure Paralysis and The Buoniconti Fund.

摘要:

性别是否会对脊髓损伤恢复造成任何影响仍然值得商榷。过去旨在解决这一问题的实验和临床研究还不能确切断定性别差异在脊髓受伤后运动恢复的程度或速度中是否存在显著区别。我们最近的一项研究采用了大样本量对男性和女性脊髓损伤实验对象进行对比,在考虑到跨性别动物年龄和体重差异之后,他的研究团队提出女性实验对象在组织保存和功能恢复中具有显著的性别优势。这对于每年一万多新增女性脊髓损伤病例来说是一个重大发现。通过提出为什么存在性别优势这一观点,可以为初始创伤的男性患者提供潜在的新治疗策略设计,并可以增强针对女性患者的神经保护效果。

Abstract:

It has been controversial whether gender has any effect on recovery following spinal cord injury (SCI). Past experimental and clinical research aimed at addressing this subject has led to constrasting
findings on whether females hold any advantage in locomotor recovery. Additionally, for studies supporting the notion of a female gender related advantage, a definite cause has not been explained. In a recent study, using large sample sizes for comparative male and female spinal cord injury cohorts, we reported that a significant gender advantage favoring females existed in both tissue preservation and functional recovery after taking into consideration discrepancies in age and weight of the animals across sexes. Prior animal research frequently used sample sizes that were too small to determine significance with certainty and also did not account for two other factors that influence locomotor performance: age and weight. Our finding is important in light of controversy surrounding the effect of gender on outcome and the fact that SCI affects more than ten thousand new individuals annually, a population that is disproportionately male. By deepening our understanding of why a gender advantage exists, potential new therapeutics can be designed to improve recovery for the male population following the initial trauma or putatively
augment the neuroprotective privilege in females for enhanced outcomes.

Key words: sex, gender, hormone, neuroprotection, estrogen, progesterone, apoptosis, Schwann cell