中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (9): 1359-1362.doi: 10.4103/1673-5374.165218

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

延时断脐可增强新生儿内源性干细胞

  

  • 收稿日期:2015-06-02 出版日期:2015-09-28 发布日期:2015-09-28

Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping

Christopher Lawton, Sandra Acosta, Nate Watson, Chiara Gonzales-Portillo, Theo Diamandis, Naoki Tajiri, Yuji Kaneko, Paul R. Sanberg,  Cesar V. Borlongan   

  1. Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
  • Received:2015-06-02 Online:2015-09-28 Published:2015-09-28
  • Contact: Cesar V. Borlongan, Ph.D., cborlong@health.usf.edu.
  • Supported by:

    CVB is funded by NIH NINDS RO1 1R01NS071956-01, NIH NINDS 1R21NS089851-01, Department of Defense TATRC W811XWH-11-1-0634, Veterans Affairs BX001407-01A2, James and Esther King Biomedical Research Program 09KB-01-23123, and 1KG01-33966.

摘要:

目前临床医生和科学家对断脐的适当或最佳时机还没有达成共识。然而,许多临床研究已经表明,延迟钳夹脐带会给新生儿带来诸多好处,包括增加血容量,减少输血需要,增强早产儿脑氧合,以及降低足月儿缺铁性贫血的患病概率。人体脐带血中含有大量的干细胞和祖细胞,并且这两种细胞已应用于治疗多种致命性疾病当中。这篇综述文章建议应该鼓励延迟钳夹脐带,因为它增加了从胎盘向新生儿的血流量,这一过程同时伴随着增加有价值的干细胞和祖细胞供给,并减少婴儿对新生儿和与年龄有关疾病的易感性。

Abstract:

There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood contains significant amounts of stem and progenitor cells and is currently used in the treatment of several life-threatening diseases. We propose that delayed cord clamping be encouraged as it enhances blood flow from the placenta to the neonate, which is accompanied by an increase supply of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase blood volume, altogether reducing the infant’s susceptibility to both neonatal and age-related diseases.

Key words: stem cells, umbilical cord blood, neonates, regenerative medicine