中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (9): 1373-1375.doi: 10.4103/1673-5374.165220

• 观点:颅神经损伤修复保护与再生 • 上一篇    下一篇

海德堡神经音乐治疗:有助于耳鸣患者听觉皮层神经再生吗?

  

  • 收稿日期:2015-06-16 出版日期:2015-09-28 发布日期:2015-09-28

Neural correlates of the Heidelberg Music Therapy: indicators for the regeneration of auditory cortex in tinnitus patients?

Christoph M. Krick, Heike Argstatter   

  1. Department of Neuroradiology, Saarland University Hospital, D-66241 Homburg, Germany (Krick CM)
    German Center for Music Therapy Research (Viktor Dulger Institute) DZM, D-69123 Heidelberg, Germany (Argstatter H)
  • Received:2015-06-16 Online:2015-09-28 Published:2015-09-28
  • Contact: Christoph M. Krick, Ph.D., christoph.krick@uniklinikum-saarland.de.
  • Supported by:

    The study was supported by KTS Klaus Tschira Stiftung gGmbH. And many thanks to Dr. Carrie Ankerstein for stylistic and linguistic improvement of this paper.

摘要:

耳鸣,指无需外部声源产生的振动或嗡嗡声在耳边响起的现象,是耳鼻咽喉科最常见的症状之一。目前耳鸣相关的干预措施主要包括使耳鸣的感知和/或习惯性过程衰减,减少脑驱动声音感知的心理痛苦。然而,还没有最后的解决方案可以进行听觉的神经调节。这篇观点文章提出了合理的耳鸣神经基础模型:由于耳蜗损伤造成的周围感觉剥夺会使感觉输入的神经的敏感性降低,同时也会使中枢听觉系统的神经元活动增强。这种中枢增益能够放大“神经噪音”,从而引发听觉皮层导致耳鸣。文中提出了音乐治疗趋向耳鸣芯的底层神经回路快速神经再生。研究的目的在于更彻底地描述耳鸣患者的痛苦,提高相关的相应神经关联研究也会提出耳鸣治疗的新方法。

Abstract:

Tinnitus, the phenomenon of ringing or buzzing in the ears without an external sound source has evolved into one of the most common symptoms in otorhinolaryngology. It affects about 10 to 15% of the general population. There are now plausible models for neural basis of tinnitus, its pathogenesis and its consequences on mental health: Peripheral sensory deprivation due to cochlear damages may prompt increased neuronal activity in the central auditory system in order to adapt the neural sensitivity to the reduced sensory inputs. This central gain could over amplify the “neural noise” and thus trigger a homeostatic down-regulation of inhibitory synapses in the auditory cortical map leading to specific reorganization of the cortical representation of the tinnitus percept. Dysfunctional feedback connections from limbic regions to auditory brain areas, interacting at the thalamic level, may account for the psychological impairment.