中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (10): 1572-1573.doi: 10.4103/1673-5374.165234

• 观点:退行性病与再生 • 上一篇    下一篇

海马区中脑源性神经营养因子转录物:对神经发育和退行性变的调控

  

  • 收稿日期:2015-07-09 出版日期:2015-10-28 发布日期:2015-10-28
  • 基金资助:

    该项研究是由韩国科学,信息通信技术和未来规划(NRF-2012R1A1B4001262),韩国科技部资助的国家研究基金会以及基础科学研究计划支持

Effects of cancer therapy on hippocampus-related function

Miyoung Yang, Changjong Moon*   

  1. Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea (Yang M)
    Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea (Moon C)
  • Received:2015-07-09 Online:2015-10-28 Published:2015-10-28
  • Contact: Changjong Moon, Ph.D., moonc@chonnam.ac.kr.
  • Supported by:

    This work was supported by Wonkwang University in 2015.

摘要:

癌症治疗是对突触可塑性和海马神经发生是有影响的。海马中生成新神经元和海马神经发生减少被认定为化学疗法和放射治疗引起副作用的一个原则目标。化疗或放射治疗后,实验动物会显示出海马齿状回中神经发生和细胞增殖明显减弱减少的现象。暴露于相对高剂量γ射线(10 Gy)进行照射或甲氨蝶呤(MTX; 40 mg/kg,IP)处理会导致持久的神经发生和记忆功能改变,甲氨蝶呤辐照也会改变与突触可塑相关的信号通路。突触可塑性这都与海马神经发生密切相关,并在不同的细胞水平和不同条件下发生改变,进而影响树突生长,轴突发生,突触重塑等进程以及生成新突触等。急性和慢性癌症治疗作为工具,主要集中研究可能影响海马神经发生和突触可塑性的各种因素,这会让我们更好地了解其基本机制。

Abstract:

The process of generating new neurons in the hippocampus, or hippocampal neurogenesis, is putatively regarded as a principle target of chemotherapy- and radiotherapy-induced side effects, particularly in relation to cognitive deficits. Following chemotherapy or radiotherapy, experimental animals exhibit significant reductions in neurogenesis and cell proliferation in the dentate gyrus of the hippocampus in conjunction with memory impairments across diverse behavioral paradigms. Reductions in neurogenesis and diminished memory capabilities have also been observed following relatively low doses of ionizing radiation (e.g., 2 Gy of γ-ray and 0.8 Gy of neutrons) or cyclophosphamide treatment (40 mg/kg, intraperitoneal [i.p.]), but these changes are reversible over time. However, exposure to relatively high doses of γ-ray (10 Gy) irradiation or methotrexate (MTX; 40 mg/kg, i.p.) treatment results in long-lasting alterations of neurogenesis and memory function.