中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (9): 1369-1370.doi: 10.4103/1673-5374.165498

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

胆碱通路:如何促进中枢神经系统髓鞘的再生?

  

  • 收稿日期:2015-07-27 出版日期:2015-09-28 发布日期:2015-09-28

The choline pathway as a strategy to promote central nervous system (CNS) remyelination

Thomas Skripuletz, Ralf A. Linker, Martin Stangel   

  1. Department of Neurology, Hannover Medical School, Hannover, Germany (Skripuletz T, Stangel M)
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany (Linker RA)
    Center for Systems Neuroscience, Hannover, Germany (Stangel M)
  • Received:2015-07-27 Online:2015-09-28 Published:2015-09-28
  • Contact: Martin Stangel, M.D., Stangel.Martin@MH-Hannover.de.

摘要:

最近,作者发现了一种新的通过胆碱途径来增强髓鞘修复的机制。作者在两种多发性硬化症的动物模型中测试了胞二磷胆碱的神经保护和再生性能。首先,作者发现,从疾病诱导开始或是从疾病出现开始时应用胞二磷胆碱,可以减轻小鼠髓鞘少突胶质细胞糖蛋白诱导的实验性自身免疫性脑髓炎的临床症状。病理组织学分析表明,胞二磷胆碱对少突胶质细胞、髓鞘化和轴突再生有保护促进作用。而当疾病峰值后应用胞二磷胆碱未能表现出对疾病过程的有益效果。双环己酮草酰二腙(Cuprizone)所致髓鞘脱失动物模型是研究髓鞘再生修复的理想模型,作者没有发现胞二磷胆碱对cuprizone所致髓鞘脱失和少突胶质细胞损失的过程有任何有益影响。然而,在髓鞘再生中,胞二磷胆碱增强髓鞘修复效果。作者结果表明胞二磷胆碱对实验性自身免疫性脑髓炎Lewis大鼠是有益的。然而,取得效果的作用机制还有待我们开发。

Abstract:

The choline pathway as a strategy to promote CNS remyelination
CDP-choline showed repair promoting functions in two animal models of multiple sclerosis with a new mechanism of action. Due to the known beneficial safety profile, CDP-choline may be a promising substance for patients with multiple sclerosis, which is worth further investigations e.g., as add-on therapy to established immunmodulators.