中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (10): 1555-1557.doi: 10.4103/1673-5374.167748

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤后轴突重塑的调控

  

  • 收稿日期:2015-09-16 出版日期:2015-10-28 发布日期:2015-10-28
  • 基金资助:

    德国研究基金会、慕尼黑中心神经系统的基金

Regulation of axonal remodeling following spinal cord injury

Anne Jacobi, Florence M. Bareyre   

  1. Institute of Clinical Neuroimmunology, Ludwig-Maximilians Universität München, Munich, Germany (Jacobi A, Bareyre FM)
    Munich Cluster of Systems Neurology (SyNergy), Munich, Germany (Bareyre FM)
  • Received:2015-09-16 Online:2015-10-28 Published:2015-10-28
  • Contact: Florence M. Bareyre, Ph.D.,florence.bareyre@med.uni-muenchen.de.
  • Supported by:

    Work in FMB laboratory is supported by grants from the Deutsche Forschungsgemeinschaft (DFG, SFB870) and by the Munich Center for System Neurology (SyNergy, EXC1010). The authors thank Martin Kerschensteiner for critically reading the paper.

摘要:

脊髓损伤在内的中枢神经系统损伤是导致青壮年残疾的主要原因。以往的大量研究着重于部分脊髓损伤后功能恢复的解剖学研究,研究发现,尽管哺乳动物中枢神经系统远距离的轴突再生被限制,棘上的和椎内的轴突在损伤后可以重塑。如何及时、准确的轴突重塑对恢复损伤的脊髓功能至关重要。研究已经发现STAT3及FGF22在脊髓损伤后重塑过程中起着重要作用。但关于脊髓损伤回路的研究还在进行中。

Abstract:

Timely and accurate axonal remodeling is key to functional recovery following spinal cord injury. To therapeutically support such remodeling processes in the future we first have to unravel the molecular signals that govern their endogenous formation. Recent studies such as the ones described here identify first molecular clues but much more work is required to obtain a comprehensive molecular understanding of circuit remodeling in the injured spinal cord.