中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (1): 23-27.doi: 10.4103/1673-5374.169601

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤中的RhoA/Rho激酶

  

  • 收稿日期:2015-03-24 出版日期:2016-01-15 发布日期:2016-01-15

RhoA/Rho kinase in spinal cord injury

Xiangbing Wu 1, 3, 4, Xiao-ming Xu 1, 2, 3, 4   

  1. 1 Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA
    2 Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    3 Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    4 Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN, USA
  • Received:2015-03-24 Online:2016-01-15 Published:2016-01-15
  • Contact: Xiao-ming Xu, Ph.D.,xu26@iupui.edu.
  • Supported by:

    This work was supported by NIH NS050243, NS059622, NS073636, DOD CDMRP W81XWH-12-1-0562, DVA 1I01BX002356-01A1,  Craig H Neilsen Foundation # 296749, Wallace H. Coulter Foundation, Indiana Spinal Cord and Brain Injury Research Foundation and Mari Hulman George Endowment Funds.

Abstract:

A spinal cord injury refers to an injury to the spinal cord that is caused by a trauma instead of diseases.Spinal cord injury includes a primary mechanical injury and a much more complex secondary injury process involving inflammation, oxidation, excitotoxicity, and cell death. During the secondary injury, many signal pathways are activated and play important roles in mediating the pathogenesis of spinal cord injury.Among them, the RhoA/Rho kinase pathway plays a particular role in mediating spinal degeneration and regeneration. In this review, we will discuss the role and mechanism of RhoA/Rho kinase-mediated spinal cord pathogenesis, as well as the potential of targeting RhoA/Rho kinase as a strategy for promoting both neuroprotection and axonal regeneration.

Key words: RhoA, Rho kinase, inflammation, cell death, degeneration, regeneration, spinal cord injury