中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1756-1758.doi: 10.4103/1673-5374.169609

• 观点:退行性病与再生 • 上一篇    下一篇

茶多酚干预神经退行疾病:确实有效吗? 

  

  • 收稿日期:2015-09-25 出版日期:2015-12-07 发布日期:2015-12-07

Polyphenols for the prevention and treatment of dementia diseases

Helmut M. Hügel*, Neale Jackson   

  1. School of Applied Sciences & Health Innovations Research Institute, RMIT University, Melbourne VIC 3001, Australia
  • Received:2015-09-25 Online:2015-12-07 Published:2015-12-07
  • Contact: Helmut M. Hügel, Ph.D.,helmut.hugel@rmit.edu.au.
  • Supported by:

    For the opportunity to perform AD and dementia chemical science research, the authors thank RMIT University, School of Applied Sciences.

摘要:

饮食对人体健康具有一定的影响,从食物中摄取物质会深刻的影响细胞功能、表观遗传改变以及控制基因表达的机制。该文主要介绍了饮食干预对神经退行性病的可能疗效。草药产品中的主要弱点都是生物相容性、药代动力学和血脑屏障通透性较差。其中生物碱,萜类,多酚类化合物代表了最普遍的具有抗痴呆效果的草药成分,但目前还不清楚这些具有生物活性的植物化学物质在什么程度上可以发挥它们的治疗作用,是单一使用还是复方使用?何种剂量可达到治疗需要的足够浓度。对于阿尔茨海默病疗法,草药产品能提供更广泛的营养效果、更安全的剂量,长期应用会对阿尔茨海默病病理治疗有效吗?尽管目前关于饮食和营养的细胞能量状态、饮食相关的广泛知识还不够了解。但流行病学调查表明,营养和膳食结构习惯是患病风险的影响因素,可以有助于控制和预防慢性疾病,从而实现延缓人体衰老疾病,如阿尔茨海默病的发病,从而达到提高人类生活质量健康的总体目标。

Abstract:

Diet has a dynamic molecular impact on human health. The nature and quantity of dietary intake profoundly influences cellular functions, epigenetic alterations and mechanisms that control gene expression. The ready availability and low cost of food and the freedom of being able to eat anything does not mean that we should exploit eating practices to eat everything. Carbohydrates, lipids and proteins are the primary dietary fuels that yield metabolic energy providing body function and performance, whereas dietary phytochemicals and herbal medicines rich in polyphenols are associated with a decreased risk of several human chronic diseases, sustain the cellular molecular machinery, preventing the development of disorders, gain of toxic function and disease conditions. Natural products utilized in folk medicine have demonstrated safety profiles since they have already been utilized for decades for the treatment of disease in humans and animals, we use them as templates for the generation of analogues for the development of therapeutic compounds, and probing molecular mechanisms underlying cellular dysfunction. The major liabilities of herbal medicinal products are poor biocompatibility, pharmacokinetic profiles and BBB permeability. Alkaloids, terpenes, polyphenolic compounds represent the most prevalent classes of herbal constituents with anti-dementia benefit. It is unclear to what extent many of these bioactive phytochemicals, utilized in single or herbal formulae doses can reach the brain in sufficient concentrations and in a biologically active form to exert their neuroprotective effects. For AD therapy, herbal products offer a wider range of brain-targets, nutritional benefits, safer dosage, long-term applications and efficacious treatment of AD pathology. In conclusion, despite extensive knowledge about how diet and nutrition has advanced beyond understanding cellular energy status, diet related chronic diseases of modern society are now the single largest cause of death. Epidemiological investigations indicate that nutrition and dietary patterns are modifiable risk factors that can help limit and prevent chronic diseases, enabling the achievement of the overall objective in slowing human aging diseases such as AD and thereby improving the quality of health span of everyone.