中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1737-1738.doi: 10.4103/1673-5374.170295

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

中间神经元:脊髓损伤恢复的焦点

  

  • 收稿日期:2015-10-14 出版日期:2015-12-07 发布日期:2015-12-07

Propriospinal interneurons in the spotlight for anatomical and functional recovery after spinal cord injury

Martin Pohland, Jana Glumm*   

  1. Institute of Cell Biology and Neurobiology, Center for Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany (Pohland M, Glumm J)
    Department of Neurosurgery, HELIOS Klinikum Berlin Buch, Berlin, Germany (Glumm J)
  • Received:2015-10-14 Online:2015-12-07 Published:2015-12-07
  • Contact: Jana Glumm, M.D., jana.glumm@charite.de.
  • Supported by:

    This study was supported by DFG Grant KFO 213 and the “Else-Kröner-Fresenius-Stiftung” to JG

摘要:

德国柏林洪堡大学细胞生物学及神经生物学系Martin Pohland 博士介绍了自己实验室关于中间神经元的研究成果及未来研究的展望。Pohland 博士认为,即使在完全脊髓损伤中,仍存在中间神经元保持脊髓喙与脊髓尾连接的网络,如果能通过刺激硬膜外脊髓和运动皮层迁移进入脊髓,或者通过移植神经元前体可加强中间神经元的作用,可能会恢复损伤脊髓的功能。

Abstract:

Spinal cord injury (SCI) with consecutive paralysis below the lesion level is a severe disorder affecting the patient for the rest of his or her life. So far, there is no known fundamental intervention strategy for efficiently helping those patients regain their motor abilities, despite intense research in this area. Thus, effective treatment for those patients is still an open question. A spinal cord injury is accompanied by a primary, severe and irreversible neuronal cell death in the trauma region, followed by a secondary extensive cell necrosis in the lesion surrounding areas. Nevertheless, recent studies indicate that regeneration after spinal cord injury could be possible if three substantial steps are fulfilled: (1) reduction of the inhibitory environment at the SCI lesion site, (2) identification of a neural substrate to establish new spinal circuits, and (3) support of these circuits to form permanent, functional motor, sensory, or autonomic connections.