中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (1): 42-44.doi: 10.4103/1673-5374.175040

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

SCYL蛋白质的神经保护功能

  

  • 收稿日期:2015-11-05 出版日期:2016-01-15 发布日期:2016-01-15
  • 基金资助:

    该研究由美国黎巴嫩叙利亚联合慈善机构支持。

SCYL pseudokinases in neuronal function and survival

Stephane Pelletier   

  1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA
  • Received:2015-11-05 Online:2016-01-15 Published:2016-01-15
  • Contact: Stephane Pelletier, Ph.D.,stephane.pelletier@stjude.org.
  • Supported by:

    The author received support from the American Lebanese Syrian Associated Charities.

摘要:

Scyl1是运动神经元疾病肌肉缺陷小鼠模型的致病基因,并已证明蛋白假激酶中SCY1样家族在神经元功能和存活中的重要性。此外SCYL蛋白可以调节几个重要的细胞过程,如细胞内运输和核tRNA运转。然而,目前还不清楚这些过程是否有助于发挥SCYL蛋白的神经保护功能。虽然SCYL基因突变还没有被证明与人类疾病有关,但很可能的是小鼠SCYL蛋白在下游通路中的损失也会受到人类神经退行性疾病的影响。因此,确定SCYL蛋白的神经保护功能通路至关重要,这不仅将进一步推动我们对SCYL蛋白质功能和疾病病理生理的认识,也会为目标药物开发提供更深入地见解。文章简要地回顾了SCYL蛋白在这些过程中发挥作用的证据。

Abstract:

The generation of mice lacking SCYL1 or SCYL2 and the identification of Scyl1 as the causative gene in the motor neuron disease mouse model muscle deficient (Scyl1mdf/mdf) demonstrated the importance of the SCY1-like family of protein pseudokinases in neuronal function and survival. Several essential cellular processes such as intracellular trafficking and nuclear tRNA export are thought to be regulated by SCYL proteins. However,whether deregulation of these processes contributes to the neurodegenerative processes associated with the loss of SCYL proteins is still unclear. Here, I briefly review the evidence supporting that SCYL proteins play a role in these processes and discuss their possible involvement in the neuronal functions of SCYL proteins.I also propose ways to determine the importance of these pathways for the functions of SCYL proteins in vivo.

Key words: SCY1-like, SCYL1, SCYL2, SCYL3, motor neuron, hippocampal neuron, pseudokinase, neuro- degeneration