中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (1): 53-57.doi: 10.4103/1673-5374.175042

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

巨噬细胞与周围神经损伤再生:微环境影响的作用

  

  • 收稿日期:2015-12-16 出版日期:2016-01-15 发布日期:2016-01-15

Macrophage polarization in nerve injury: do Schwann cells play a role?

Jo Anne Stratton 1, 2, 3, Prajay T. Shah 2, 3   

  1. 1 Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    2 Hotchkiss Brain Institute, Calgary, Canada
    3 Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
  • Received:2015-12-16 Online:2016-01-15 Published:2016-01-15
  • Contact: Jo Anne Stratton, Ph.D.,jo.stratton@ucalgary.ca.

摘要:

周围神经损伤后,其远侧的轴突发生变化直接导致神经纤维受损中断、远端轴突坏死、髓鞘分解消失和神经鞘膜增生等一系列蜕变和细胞吞噬过程。在轴突溃变、丢失的反应的刺激下,雪旺细胞开始重新分化。周围神经损伤后,损伤部位免疫应答具有以下几个共同特点:免疫细胞的快速流入,早期促炎性反应发生,刺激机体产生抗炎反应。目前为止,周围神经损伤后包括巨噬细胞和雪旺细胞在内的潜在的细胞相互作用还未明确。需要进一步的研究来完全解开巨噬细胞高效周围神经损伤再生中的潜在贡献。

Abstract:

In response to peripheral nerve injury, the inflammatory response is almost entirely comprised of infiltrating macrophages. Macrophages are a highly plastic, heterogenic immune cell, playing an indispensable role in peripheral nerve injury, clearing debris and regulating the microenvironment to allow for efficient regeneration.There are several cells within the microenvironment that likely interact with macrophages to support their function – most notably the Schwann cell, the glial cell of the peripheral nervous system. Schwann cells express several ligands that are known to interact with receptors expressed by macrophages, yet the effects of Schwann cells in regulating macrophage phenotype remains largely unexplored. This review discusses macrophages in peripheral nerve injury and how Schwann cells may regulate their behavior.

Key words: nerve, macrophage, traumatic injury, Schwann cells, polarization