中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (2): 214-214.doi: 10.4103/1673-5374.177715

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

高、低剂量多巴胺在调节抑制神经传输与可塑性中的作用

  

  • 收稿日期:2015-12-11 出版日期:2016-02-15 发布日期:2016-02-15
  • 基金资助:

    该研究由美国国家科学和技术理事会,国家科学技术委员会81062资助

Dopamine regulation of striatal inhibitory transmission and plasticity: dopamine, low or high?

Elizabeth Hernández-Echeagaray   

  1. Laboratorio de Neurofisiología del Desarrollo y la Neurodegeneración, Unidad de Biomedicina, FES-I, Universidad Nacional Autónoma de México, Los Reyes Iztacala, C.P., Tlalnepantla México
  • Received:2015-12-11 Online:2016-02-15 Published:2016-02-15
  • Contact: Elizabeth Hernández-Echeagaray, Ph.D.,elihernandez@campus.iztcala.unam.mx or aehe67@gmail.com.
  • Supported by:

    This work was supported by Consejo Nacional de Ciencia y Tecnología,CONACYT-81062.

摘要:

纹状体是原子核基底神经节的主要输入,通过对纹状体突触选择性调制,黑质纹状体系统直接作用于多巴胺并参与了解其运动过程。在中型多棘神经元中,多巴胺的调节行为很好的描述了皮质连接和谷氨酸的释放。中型多棘神经元的上皮层影响十分重要,但在纹状体内还存在其它神经元亚型,其会与中型多棘神经元建立连接并形成局部电路。谷氨酸能突触输入到中型多棘神经元来自其他中型多棘神经元轴突网络,以及来自中间神经元,这种突触会影响中型多棘神经元的活性形成,并且两者都通过多巴胺进行调制。我们研究组最近发表的结果表明,多巴胺对谷氨酸能中间神经元的调节作用会抑制突触。然而,此类突触诱导的长期可塑性除了依赖于多巴胺浓度外,也于D1或D2的活化受体亚型有关。

Abstract:

The striatum is the principal input nuclei to the BG and the DA through direct action of the nigrostriatal system on striatal synapses, selects and modulates learned motor programs. Modulatory actions of DA on Medium Spiny Neurons (MSNs) are very well described in relation to corticostriatal connection and glutamatergic release. Even the importance of cortical influences on MSN, there are other neuronal subtypes inside of the striatum, which establish connection with MSN and form the local circuits. GABAergic synaptic inputs to MSNs come from axonal collaterals of other MSNs, as well as, from interneurons, this synaptic influences shape MSNs activity, and both are modulated by DA. We have recently published that the net modulatory effect of DA on inhibitory synapses that GABAergic interneuron’s made on MSNs, is a decrease in the amplitude of the inhibitory postsynaptic current (IPSC). However the long term plasticity induced in this synapses (GABAergic interneuron’s-MSNs) depends on the DA concentration in addition to the activation of D1 or D2 receptors subtype. High Frequency Stimulation (HFS) in low DA concentration (200 nM) produced mostly LTD, whereas high concentration of DA (20 µM) favored the generation of LTP.