中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (2): 217-219.doi: 10.4103/1673-5374.177716

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

聚乙二醇细胞融合技术可延迟沃勒变性和快速恢复神经切断后丢失的功能

  

  • 收稿日期:2016-02-15 出版日期:2016-02-15 发布日期:2016-02-15
  • 基金资助:

    美国NIH基金;Lone Star瘫痪研究基金 

     

Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance

George D. Bittner , Michelle Mikesh, Cameron L. Ghergherehchi   

  1. Department of Neuroscience, University of Texas at Austin, Austin, TX, USA
  • Received:2016-02-15 Online:2016-02-15 Published:2016-02-15
  • Contact: George D. Bittner, Ph.D.,bittner@austin.utexas.edu.
  • Supported by:

    This study was supported by grants from the Lone Star Paralysis Foundation and an NIH grant R01 NS081063 to GDB.

摘要:

研发聚乙二醇融合技术的初衷是帮助恢复周围神经断裂或消融后丧失的多项运动机能,但近来有报道指出该项技术也有助于恢复脊椎损伤后丧失的多项运动机能。“聚乙二醇)融合”技术的原理相对于“防止或延缓华勒变性说”来讲,更大程度地体现为该技术具有神经保护作用,能够防止受损神经元坏死。“聚乙二醇(PEG)融合”技术在周围神经发生完全性轴突断裂后能够延缓华勒变性和快速恢复丧失的运动机能,虽然其具体的作用机理尚不明确,但可以肯定的是聚乙二醇融合技术能够很好地应用于临床治疗当中,因为基于聚乙二醇研发的全部药物均无毒副作用,在使用时效上立等可取,而且已经通过了食品与药品监督管理局的批准,可应用于人体治疗。鉴于已经出现过成功的神经组织移植修复案例,我们建议组织库考虑能否在储藏供体眼角膜、肝脏和心脏等脏器的同时一同储藏供体的神经组织。

Abstract:

While the specific mechanisms responsible for retarding Wallerian degeneration and rapidly restoring behaviors lost after complete axonal severance of peripheral nerves are not yet known, PEG-fusion may translate well to clinical procedures since all drugs are benign, readily available, and are already FDA-approved for human use. Successful allograft repair suggests that tissue banks might consider the inclusion of donor nerve tissue alongside donor corneas, livers, hearts, etc. This PEG-fusion technology developed to restore many behaviors lost after peripheral nerve severance or ablation has also recently been reported to restore many behaviors lost after spinal contusion injuries.