中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (2): 220-221.doi: 10.4103/1673-5374.177717

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

化学和物理方法促进神经突生成和周围神经再生中的应用

  

  • 收稿日期:2016-01-28 出版日期:2016-02-15 发布日期:2016-02-15

Effects of chemical and physical cues in enhancing neuritogenesis and peripheral nerve regeneration

Casey D. Sigerson, Christopher J. Dipollina, Michele Fornaro   

  1. Department of Anatomy, Midwestern University - Chicago College of Osteopathic Medicine, Downers Grove, IL, USA (Sigerson CD, Fornaro M)
    Department of Biomedical Sciences, Midwestern University, College of Health Sciences, Downers Grove, IL, USA (Dipollina CJ)
  • Received:2016-01-28 Online:2016-02-15 Published:2016-02-15
  • Contact: Michele Fornaro, Ph.D.,mforna@midwestern.edu.

摘要:

文章重点阐述了促进周围神经系统神经再生的各种方法。第一,介绍了以化学信号、生长因子和ECM为主的各种促进神经再生的传统方法,第二,介绍了能够影响轴突生长及生长方向的更新的物理信号概念。美国中西州立大学解剖系Michele Fornaro副教授实验室尝试将化学和物理这两种方式相结合,完善神经突生成和轴突生长的方法。

Abstract:

Developing a model that incorporates several of the relevant factors would be of great interest to the field of neuroregeneration. The creation of microenvironments that simultaneously address topography, bound ECM cues and free neurotrophic factors would allow researchers to test for possible additive or synergistic effects due to the combination of factors. Only myriad combinations of biophysical and biochemical cues will allow neuroscientists to elucidate the optimal environment for neuroregeneration. Discoveries in the area of in vitro regeneration will lead to the most important goal for this field of research: the modification of the neural microenvironment in vivo to promote axonal growth and restore neural function.