中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (2): 230-231.doi: 10.4103/1673-5374.177721

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

腱糖蛋白-C 在动脉瘤性蛛网膜下出血治疗中的作用:“加剧恶化”还是“有效保护”?

  

  • 收稿日期:2016-02-04 出版日期:2016-02-15 发布日期:2016-02-15

Tenascin-C in aneurysmal subarachnoid hemorrhage: deleterious or protective?

Hidenori Suzuki, Fumihiro Kawakita   

  1. Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Japan
  • Received:2016-02-04 Online:2016-02-15 Published:2016-02-15
  • Contact: Hidenori Suzuki, M.D., Ph.D.,suzuki02@clin.medic.mie-u.ac.jp.

摘要:

脑动脉瘤破裂引起的蛛网膜下出血是为大家所熟知的一种严重脑血管疾病。对动脉瘤性蛛网膜下出血患者加强监察护理的第一步就是切除动脉瘤止血,从而防止动脉再次出血对因早期脑损伤原本就很脆弱的脑组织造成二次伤害。在后续的治疗过程当中,需要对患者进行缜密细致的医疗护理,控制脑积水、脑血管痉挛以及迟发性脑缺血等并发症的出现。虽然目前针对蛛网膜下出血患者的临床护理有了较大的提高和改善,但对那些从初次脑出血当中幸运逃过一劫的蛛网膜下出血患者来说,迟发性脑缺血仍是最主要的致病和致死因素之一。近期研究表明早期脑损伤和脑血管痉挛是诱发迟发性脑缺血的因素,但早期脑损伤、脑血管痉挛和迟发性脑缺血的发病机理仍是一个未解之谜,这便成为了科研人员研发治疗这些疾病新疗法征程上的一只拦路虎。

Abstract:

Subarachnoid hemorrhage (SAH) caused by the rupture of a cerebral aneurysm is a well-known devastating cerebrovascular disease. Post-SAH brain is vulnerable, associated with early brain injury. The first step for intensive care of aneurysmal SAH patients is aneurysmal obliteration to prevent rebleeding as well as further aggravation of EBI. The subsequent treatment requires intensive medical care to manage the associated problems including hydrocephalus, cerebral vasospasm and delayed cerebral ischemia (DCI). Despite improvements in the clinical management of SAH, DCI remains one of the most important causes of morbidity and mortality in SAH patients who survive the initial bleeding. Recently, EBI as well as cerebral vasospasm is considered to be a cause of DCI (Suzuki, 2015). However, the pathogenesis of EBI, cerebral vasospasm and DCI remains unclear, precluding the development of new therapies against them.