中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (2): 228-229.doi: 10.4103/1673-5374.177747

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

微创治疗出血性和缺血性脑卒中的研究与应用进展

  

  • 收稿日期:2015-11-19 出版日期:2016-02-15 发布日期:2016-02-15

Advances in minimally invasive treatment of hemorrhagic and ischemic stroke

Robert C. Rennert, J. Scott Pannell, Alexander A. Khalessi   

  1. Department of Neurosurgery, University of California - San Diego, La Jolla,CA, USA
  • Received:2015-11-19 Online:2016-02-15 Published:2016-02-15
  • Contact: Alexander A. Khalessi, MD, MS, FAANS, FAHA,akhalessi@ucsd.edu.

摘要:

我们都知道脑血管疾病,包括脑卒中,会导致中枢神经系统敏感度在血流中断中的高水平发病率和死亡率。脑卒中对传统的外科手术措施具有免疫性,但微创技术由于其可最小化二次神经损伤已经在脑出血以及缺血性脑卒中治疗中得到了较高的利用率。我们近期的研究工作迅速扩大了针对出血性脑卒中内镜疏散的全身检验,以及机械性血栓对缺血性脑卒中的治疗贡献。具体来说,文章强调了我们实验室极具优势的研究发现并利用联合神经导航/神经内镜的血块疏散技术,而我们的新工作旨在开发一种体外活细胞平台,能够跨设备检测血栓表征内皮损伤的模式和机制。

Abstract:

Cerebrovascular diseases, including ischemic and hemorrhagic strokes, affect more than 6 million US adultsannually. Strokes cause high rates of morbidity and mortality due to the central nervous system’s sensitivity to disruptions in blood flow, and are refractory to traditional surgical interventions. A variety of minimally invasive surgical and endovascular approaches have recently been developed to improve outcomes patient outcomes following stroke. As research in other surgical fields has demonstrated multiple advantages of minimally invasive techniques, including avoidance of large incisions requiring less sedation, less trauma to the patient, and potentially lower treatment costs resulting from shorter hospital courses and a reduced need for post-operative intensive medical care, it is no surprise that minimally invasive surgical approaches to stroke have recently gained traction. As highlighted herein, the successful development and integration of such technology requires a strong pre-clinical foundation and well designed clinical trials. The promising results in the aforementioned and ongoing clinical trials suggest the future utilization of minimally invasive techniques for the treatment of hemorrhagic and ischemic stroke will continue to increase.