中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (3): 410-411.doi: 10.4103/1673-5374.179048

• 观点:退行性病与再生 • 上一篇    下一篇

多发性硬化和视神经脊髓炎谱系障碍:两种不同疾病的相似之处

  

  • 收稿日期:2016-02-20 出版日期:2016-03-15 发布日期:2016-03-15

Multiple sclerosis and neuromyelitis optica spectrum disorders: some similarities in two distinct diseases

Hiroaki Yokote, Hidehiro Mizusawa   

  1. Department of Neurology, Nakano General Hospital, Tokyo, Japan Department of Neurology and Neurological Sciences, Tokyo Medical and Dental University, Tokyo, Japan (Yokote H)
    Department of Neurology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan (Mizusawa H)
  • Received:2016-02-20 Online:2016-03-15 Published:2016-03-15
  • Contact: Hidehiro Mizusawa, M.D., Ph.D.,mizusawa@ncnp.go.jp.

摘要:

视神经脊髓炎谱系疾病(NMOSD)被认为是一种亚洲的脊髓型多发性硬化,这是一种专门损害视神经和脊髓的中枢神经系统慢性炎症疾病,虽然这两种疾病在本质上是不同的,但是最近的研究发现,MS和NMOSD之间有一些相似之处。在这篇文章中,我们重点研究MS和NMOSD之间的相似之处并从病理学,影像学,免疫学理论出发讨论这些相似之处的联系以及疾病的发病机制。无论患者被诊断为MS或是NMOSD,每个患者的免疫学和病理学背景都应该被考虑到临床实践和基础研究之中。

Abstract:

There are some similarities between MS and NMOSD, although these 2 diseases are essentially distinct. Understanding the similarities between MS and NMOSD helps us to see an atypical case that is the borderline between MS and NMOSD. It is essential to choose carefully an appropriate treatment based on the nature of the lesion and the pathophysiological background: IFN-β should be avoided for this borderline patient at least since the disease can be mediated by Th17.