中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (4): 554-556.doi: 10.4103/1673-5374.180733

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

细胞外基质技术和外核体免疫调节对中枢神经系统损伤的修复

  

  • 收稿日期:2016-03-22 出版日期:2016-04-30 发布日期:2016-04-30
  • 基金资助:

    美国国会指导医学研究项目;医疗卫生研究基金;宾夕法尼亚州狮子会视力保护与眼科研究基金会资助项目;NIH基金等。

Immunomodulatory approaches to CNS injury: extracellular matrix and exosomes from extracellular matrix conditioned macrophages

Yolandi van der Merwe, Michael B. Steketee*   

  1. Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA (van der Merwe Y) Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA (van der Merwe Y, Steketee MB) Center for Neuroscience University of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA (Steketee MB)
  • Received:2016-03-22 Online:2016-04-30 Published:2016-04-30
  • Contact: Michael B. Steketee, Ph.D., SteketeeM@UPMC.edu.
  • Supported by:

    We gratefully acknowledge funding from the Department of Defense office of the Congressionally Directed Medical Research Programs and the Clinical and Rehabilitative Medicine Research Program (MBS, MR130444), Competitive Medical Research Fund, University of Pittsburgh (MBS), Pennsylvania Lions Sight Conservation & Eye Research Foundation (MBS), Sterling Lions Club of Pennsylvania and Dance for Sight (MBS), Start-up funds, Department of Ophthalmology, University of Pittsburgh (MBS), National Institutes of Health CORE Grant P30 EY008098, Eye and Ear Foundation of Pittsburgh, PA, Unrestricted Grant from Research to Prevent Blindness, New York, NY.

摘要:

先天免疫反应在高等哺乳动物中枢神经系统损伤再生中起着很大的作用。利用天然来源的生物学因素新的免疫调节技术转化成为预防或甚至恢复中枢神经系统损伤后丢失的神经功能的手段。通过改善在中枢神经系统损伤后促炎性反应,而不是抑制免疫系统的抗炎作用,中枢神经系统功能恢复正成为可能。虽然集中于靶向特定的细胞群中的多个细胞内信号通路的组合疗法已显示,中枢神经系统神经元可以再生长距离重新支配在大脑中的目标,但这些方法未能解决轴突生长过程中细胞外基质微环境中的变化,瘢痕形成,抑制轴突的再生。细胞外基质技术可能被载入针对不同的细胞群改造的外核体。用于治疗在中枢神经系统神经炎症性疾病的主要障碍是缺乏一个优化可允许药物穿过血脑屏障或穿透中枢神经系统的更深区域的递送策略。细胞外基质技术由于其具有免疫原性低,可有效地输送的范围内的生物分子的能力,与靶细胞的宿主相互作用,可传递药物到达全身甚至鞘内注射进入中枢神经系统等特点,将成为中枢神经系统损伤治疗的潜在工具。

orcid: 0000-0002-0269-8671 (Yolandi van der Merwe)