中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (5): 693-697.doi: 10.4103/1673-5374.182680

• 综述:退行性病与再生 •    下一篇

果蝇眼睛是阿尔茨海默病的经典模型?

  

  • 收稿日期:2016-03-03 出版日期:2016-05-20 发布日期:2016-05-20

Alzheimer’s disease: the silver tsunami of the 21st century

Ankita Sarkar1, #, Madison Irwin1, #, Aditi Singh1, §, Matthew Riccetti1, Amit Singh1, 2, 3, 4, *   

  1. 1 Department of Biology, University of Dayton, Dayton, OH, USA
    2 Premedical Program, University of Dayton, Dayton, OH, USA 3 Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, USA"
  • Received:2016-03-03 Online:2016-05-20 Published:2016-05-20
  • Contact: Amit Singh, Ph.D., asingh1@udayton.edu.

摘要:

文章讨论了果蝇眼睛模型用于研究阿尔茨海默病的效用,阿尔茨海默病,是一种致命性且目前还无法治愈的神经退行性疾病。导致阿尔茨海默病的原因之一是淀粉样蛋白β42积累造成神经变性发作。目前还不知道这些斑块触发神经变性发作时发出的是何种信号。目前阿尔茨海默病动物模型主要用于研究(ⅰ)疾病病因,(ⅱ)寻找遗传改性剂,和(iii)确定化学抑制剂并找到治愈这种疾病的治疗方法。果蝇昆虫模型也为阿尔茨海默病研究提供了新选择。

orcid: 0000-0002-2962-2255(Amit Singh)

Abstract:

Alzheimer’s disease (AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42 (Aβ42) plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to (i) study etiology of disease, (ii) look for genetic modifiers, and (iii) identify chemical inhibitors that can block neurodegeneration and help to find cure for this disease. An insect model of Drosophila melanogaster has also provided new insights into the disease. Here we will discuss the utility of the Drosophila eye model to study Alzheimer’s disease.

Key words: Alzheimer’s disease, neurodegeneration, amyloid plaques, amyloid hypothesis, animal models, drosophila melanogaster, drosophila eye