中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (8): 1204-1207.doi: 10.4103/1673-5374.189162

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

TRPV1可能有效增强雌激素在神经保护和神经再生方面的作用

  

  • 出版日期:2016-08-31 发布日期:2016-08-31
  • 基金资助:
    我们的研究得到了补助金科技基金11100047-11110399-ECOS12029支持。

TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration

Ricardo Ramírez-Barrantes, Ivanny Marchant, Pablo Olivero*   

  1. Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile
  • Online:2016-08-31 Published:2016-08-31
  • Contact: Pablo Olivero, Ph.D., pablo.olivero@uv.cl
  • Supported by:
    Our work has been supported by grants Fondecyt1140693 - 11100047- 11110399 - ECOS 12029.

摘要:

生殖老化甚至先于更年期或更年期临床表现,也是性行为和认知功能保护优化的主要决定因素。因此,在老化过程中控制神经内分泌变化可能是至关重要的,同时通过神经保护或神经发生保持性行为和改善脑功能。雌激素替代疗法可降低更年期妇女记忆混乱的风险。无论是局部给药或外源性类固醇都可以提供神经保护和神经再生作用。具体来说,外源性雌激素可以增加树突棘在海马区的形成以及去势雌性小鼠内侧前额叶皮层,进而支持其对记忆的可能有益影响。这些发现增加了使用雌激素受体配体对绝经后妇女认知能力改善的新信息。有充分的证据表明雌激素和它们的代谢物能够促进再生、可塑性和神经系统的健康状况,然而其水平的降低或减少与身体受损和精神健康相关,并会增加心血管和神经退行性疾病的风险。Pablo Olivero教授提出瞬时受体电位离子通道家族,特别是TRPV1,可以作为类固醇离子型受体为神经保护和神经再生提供一个新的药物靶点。

orcid: 0000-0001-8886-7206 (Pablo Olivero)

Abstract: Aging induces physical deterioration, loss of the blood brain barrier, neuronal loss-induced mental and neurodegenerative diseases. Hypotalamus-hypophysis-gonad axis aging precedes symptoms of menopause or andropause and is a major determinant of sensory and cognitive integrated function. Sexual steroids support important functions, exert pleiotropic effects in different sensory cells, promote regeneration, plasticity and health of the nervous system. Their diminution is associated with impaired cognitive and mental health and increased risk of neurodegenerative diseases. Then, restoring neuroendocrine axes during aging can be key to enhance brain health through neuroprotection and neuroregeneration, depending on the modulation of plasticity mechanisms. Estrogen-dependent transient receptor potential cation channel, subfamily V, member 1 (TRPV1) expression induces neuroprotection, neurogenesis and regeneration on damaged tissues. Agonists of TRPV1 can modulate neuroprotection and repair of sensitive neurons, while modulators as other cognitive enhancers may improve the survival rate, differentiation and integration of neural stem cell progenitors in functional neural network. Menopause constitutes a relevant clinical model of steroidal production decline associated with progressive cognitive and mental impairment, which allows exploring the effects of hormone therapy in health outcomes such as dysfunction of CNS. Simulating the administration of hormone therapy to virtual menopausal individuals allows assessing its hypothetical impact and sensitivity to conditions that modify the effectiveness and effciency.

Key words: TRPV1, estrogen, hormonal replacent, neuroprotection, aging