中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (8): 1220-1223.doi: 10.4103/1673-5374.189168

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

异源受体体积传输和受体-受体交互作用:理解大脑沟通和整合的新概念

  

  • 出版日期:2016-08-31 发布日期:2016-08-31
  • 基金资助:
    瑞典医学研究理事会资助

Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication

Kjell Fuxe1, *, Dasiel O. Borroto-Escuela1, 2, *   

  1. 1 Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden 2 Observatorio Cubano de Neurociencias, Grupo Bohío-Estudio, Yaguajay, Cuba
  • Online:2016-08-31 Published:2016-08-31
  • Contact: Kjell Fuxe, M.D. or Dasiel O. Borroto-Escuela, Ph.D., kjell.fuxe@ki.se or dasiel.borroto.escuela@ki.se.
  • Supported by:
    The authors are supported by grants from the Swedish Medical Research Council (04X-715) to KF, by AFA F?rs?kring (130328) to KF and DOBE, and by Hj?rnfonden to DOBE. DOBE belong to Academia de Biólogos Cubanos.

摘要:

细胞外囊泡(外来体和脱落囊泡)介导的一种特殊形式的中枢神经系统容积传输方式。在这种新型的容积传输中,细胞外囊泡成为中枢神经系统内受体和同源异型蛋白(质),线粒体DNA和不同形式的RNA沿能量梯度细胞外液迁移到相邻靶细胞的安全的囊泡载体。与布线传输相比较,容积传输的速度慢,作用范围大,专一性低,涉及的细胞及分子类型多。由于容积传输发生在细胞外液中,细胞外基质的结构及细胞外液的流动方式对容积传输有很大影响。另外,浓度梯度、电场梯度、温度梯度和压力梯度等物理因素是容积传输的动力来源,其自身能量消耗较低。容积传输有3种形式:短距离的突触外容积传输、长距离的容积传输和游荡型(囊泡)的容积传输,后两种传输可达到毫米以上的距离,可以作用于其他神经末梢。此外,动脉搏动形成的潮汐式压力波以及血管和神经束周围的间隙等与容积传输也有密切关系。

orcid: 0000-0002-5736-373X (Dasiel O. Borroto-Escuela)

Abstract: The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord, but also to a novel type of communication called volume transmission. It is a major mode of communication in the central nervous system that takes places in the extracellular ?uid and the cerebral spinal ?uid through diffusion and ?ow of molecules, like neurotransmitters and extracellular vesicles. The integration of synaptic and volume transmission takes place through allosteric receptor-receptor interactions in heteroreceptor complexes. These heterocomplexes represent major integrator centres in the plasma membrane and their protomers act as moonlighting proteins undergoing dynamic changes and their structure and function. In fact, we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses.

Key words: volume transmission, receptor-receptor interaction, heteroreceptor complexes, oligomerization, brain communication, learning, memory, central monoamine neurons