中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (10): 1540-1544.doi: 10.4103/1673-5374.193221

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

在心室区神经前体细胞靶向删除泛连接蛋白1的神经功能改变

  

  • 收稿日期:2016-10-14 出版日期:2016-10-31 发布日期:2016-10-31
  • 基金资助:
    Swayne实验室研究由加拿大自然科学和工程研究理事会(NSERC发现基金),加拿大健康研究所(CIHR基金MOP142215),加拿大苏格兰礼慈善基金会,来自加拿大学院运营补助的维多利亚大学医学科学部,加拿大创新基金会和不列颠哥伦比亚省知识发展基金的基础设施补助。 L.A.S.由迈克尔?史密斯基金会健康研究和不列颠哥伦比亚省精神分裂症社会基金会学者奖支持。 J.C.S.A.由维多利亚大学奖学金研究生奖支持。 L.E.W.S.由加拿大凡尼尔研究生奖学金支持。

Perspectives on the role of Pannexin 1 in neural precursor cell biology

Juan C. Sanchez-Arias1, Leigh E. Wicki-Stordeur1, Leigh Anne Swayne1, 2, *   

  1. 1 Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada 2 Island Medical Program and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
  • Received:2016-10-14 Online:2016-10-31 Published:2016-10-31
  • Contact: Leigh Anne Swayne, Ph.D., lswayne@uvic.c
  • Supported by:
    Research in the Swayne lab was supported by operating grants to LAS from the Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant), the Canadian Institutes of Health Research (CIHR Grant MOP142215), Te Scottish Rite Charitable Foundation of Canada and the University of Victoria Division of Medical Sciences and by infrastructure grants from the Canadian Foundation for Innovation (CFI) and the British Columbia Knowledge Development Fund (BCKDF). LAS was supported by a Michael Smith Foundation for Health Research and British Columbia Schizophrenia Society Foundation Scholar Award. JCSA was supported by a University of Victoria Fellowship Graduate Award. LEWS was supported by a Vanier Canada Graduate Scholarship (NSERC)

摘要:

文章最近报道了在心室区神经前体细胞中靶向删除泛连接蛋白1(Pannexin 1),会影响这些细胞在健康和脑卒中损伤大脑中的稳定性。作者梳理了研究团队以前关于神经前体Pannexin 1的研究新发现,以及其他团队对Pannexin 1与嘌呤受体之间密切关系的见解。此外,文章找出了Pannexin1在神经前体细胞生物学作用中重要的分子机制和功能及行为结果。

orcid: 0000-0002-8061-7128 (Juan C. Sanchez-Arias) 0000-0002-3235-4108 (Leigh E. Wicki-Stordeur) 0000-0001-5852-3144 (Leigh Anne Swayne)

Abstract: We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new fnding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close relationship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the underlying molecular mechanisms and functional/behavioural outcomes.

Key words: neural precursor, ventricular zone, pannexin, ATP, cytoskeleton, proliferation, phagoptos