中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (10): 1560-1563.doi: 10.4103/1673-5374.193226

• 综述:退行性病与再生 • 上一篇    下一篇

神经元功能的恢复:神经退行性眼病的治疗方向

  

  • 收稿日期:2016-09-26 出版日期:2016-10-31 发布日期:2016-10-31
  • 基金资助:
    BrightFocus基金会全国青光眼研究项目;防盲研究;NIH基金

Neuro-rejuvenation for neuronal function

Yuan Liu, Richard K. Lee*   

  1. Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA
  • Received:2016-09-26 Online:2016-10-31 Published:2016-10-31
  • Contact: Richard K. Lee, M.D., Ph.D., RLee@med.miami.edu.
  • Supported by:
    The work was supported by the National Glaucoma Research Program of the Bright Focus Foundation. The Bascom Palmer Eye Institute is supported by an unrestricted research grant from Research to Prevent Blindness and NIH center grant EY014801.

摘要: 干细胞移植、神经修复和神经再生是神经退行性眼病备受关注的三种治疗策略。与干细胞治疗相比,移植的细胞中有不确定的细胞因素,融入神经回路困难和神经再生时达到正确的神经元地面临的挑战。利用现有的视网膜神经节细胞和神经元网络,神经复壮提供了更广阔的和实用的方法。而非引入新的细胞进入视网膜或刺激那些死亡的视网膜神经元,神经修复的重点在于现有的细胞,通过加强他们的功能,使现有的神经元细胞,帮助生病的细胞,并加强现有的连接,以增加现有的信号达到噪声比。神经再生的进一步了解将揭示神经退行性眼病的治疗,并给那些患有视力丧失的患者恢复光明带来希望。

Abstract: Neurodegenerative eye diseases, such as glaucoma, cause irreversible vision loss in millions of patients worldwide, creating serious medical, economic and social issues. Like other mammalian central nervous system tracts, optic nerve intrinsically lacks the capacity for axonal growth and its surrounding environment is also non-permissive to regeneration. Any axonal damage also triggers a vicious cycle of retinal ganglion cell (RGC) death. Exploring methods that can enhance RGCs survival and promote axonal regeneration will not only enable vision restoration for millions of patients, but also shed light on the treatment of other neurodegenerative diseases. In this review article, we will go through three current approaches to cure neurodegenerative eye diseases, including cell based therapy, neuro-regeneration and neuro-rejuvenation.