中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (10): 1568-1569.doi: 10.4103/1673-5374.193230

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

3D打印的神经导管

  

  • 收稿日期:2016-09-19 出版日期:2016-10-31 发布日期:2016-10-31
  • 基金资助:
    这项研究由马里兰干细胞研究基金(2013-MSCRFE-146-00)(XJ),部分由美国国立卫生研究院(R01HL118084)(XJ)支持

3D printed nerve guidance channels: computer-aided control of geometry, physical cues, biological supplements and gradients

Blake N. Johnson*, Xiaofeng Jia*   

  1. Department of Industrial and Systems Engineering, School of Neuroscience, Virginia Tech, Blacksburg, VA, USA (Johnson BN) Department of Neurosurgery, Orthopaedics, Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore,MD, USA (Jia X) Department of Biomedical Engineering, Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA (Jia X)
  • Received:2016-09-19 Online:2016-10-31 Published:2016-10-31
  • Contact: Blake N. Johnson, Ph.D. or Xiaofeng Jia, M.D., Ph.D., bnj@vt.edu or xjia@som.umaryland.edu.
  • Supported by:
    This work was supported by the Maryland Stem Cell Research Fund (2013-MSCRFE-146-00) (to XJ) and in part by the National Institute of Health (R01HL118084) (to XJ).

摘要:

神经导向渠道,即神经导向、神经再生途径和神经导向导管已成为一项可实现损伤周围神经再生的创新技术。受目前周围神经损伤修复的黄金标准(自体移植手术方法)启发,多种商用可用的神经导管均可以作为替代自体神经移植的材料,如合成材料和生物材料等。使用神经导管进行神经修复的“艺术”涉及可降解导管。神经导管快速修复周围神经长段缺损的能力取决于对再生的生物诱导。计算机辅助制造方法,如基于3D生物打印解剖设计提供了交织多种材料的能力,这对于加快人工神经导管的研究和促进其进一步的临床转化具有重大意义。

orcid: 0000-0003-4668-2011 (Blake N. Johnson), 0000-0003-1445-8525 (Xiaofeng Jia)