中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (11): 1727-1730.doi: 10.4103/1673-5374.194804

• 综述:退行性病与再生 • 上一篇    下一篇

神经炎症、神经退变和再生:多发性硬化症中的免疫反应相关表现

  

  • 出版日期:2016-11-30 发布日期:2016-11-30

Neuroin?ammation, neurodegeneration and regeneration in multiple sclerosis: intercorrelated manifestations of the immune response

Tatiana Koudriavtseva1, *, Caterina Mainero2   

  1. 1 Multiple Sclerosis Clinical and Research Unit, Department of Systems Medicine, Tor Vergata University, Rome, Italy 2 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USA
  • Online:2016-11-30 Published:2016-11-30
  • Contact: Tatiana Koudriavtseva, M.D., Ph.D., tatiana.koud@gmail.com.

摘要:

多发性硬化是以炎症、脱髓鞘、轴突和神经元损失为特征的中枢神经系统慢性免疫介导病症。关于多发性硬化神经变性的来源目前仍是一个有争议的问题,文章讨论了神经炎症和神经退行性疾病之间的关系,并基于临床证据和神经病理学证据,研究其与再生的关联。有充分的证据表明,在健康大脑和许多神经系统疾病中,神经炎症、神经退变和再生在免疫应答方面表现密切,包括多发性硬化。在多发性硬化症中,神经炎症和神经变性共存于再生过程中。在急性和局部损伤条件下,神经炎症可能能够连接并与神经变性相反,其可能会刺激再生。过度或慢性神经炎症会加强神经变性,反过来由于稳态保护环境受损进而又加剧了有害神经炎症发生,因此导致神经再生过程困难。就目前应对神经退行性疾病,包括多发性硬化的“战役”中,或许能够通过部分转移神经炎症对保护营养功能的作用,实现促进神经再生的目的。

orcid: 0000-0001-9984-1827 (Tatiana Koudriavtseva)

Abstract: Multiple sclerosis (MS) is a chronic immune-mediated in?ammatory-demyelinating disorder of the central nervous system, with a strong neurodegenerative component. Te question whether neurodegeneration in MS is independent or related to neuroin?ammation has been long debated, but not yet fully clarifed. Furthermore, little is still known on how neuroin?ammation and neurodegeneration in MS are related to potential regenerative processes. In this perspective, we brie?y discuss main clinical, pathological and experimental evidence on the relationship between neuroin?ammation and neurodegeneration in MS, and on their connection with regeneration. We discuss that these processes in MS might represent intercorrelated manifestations of the immune response, especially of the innate immunity.

Key words: multiple sclerosis, neuroin?ammation, neurodegeneration, regeneration, immune response, innate immunity