中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (12): 1869-1883.doi: 10.4103/1673-5374.195278

• 综述:脑损伤修复保护与再生 •    下一篇

成人脑神经发生的动态变化

  

  • 收稿日期:2016-11-18 出版日期:2016-12-31 发布日期:2016-12-31
  • 基金资助:
    这项工作得到了非洲高级研究培训联合会(CARTA)支持。 CARTA由非洲人口与健康研究中心(APHRC)和威特沃特斯兰德大学共同领导,由威康信托基金(英国)(资助号087547/Z/08/Z),国际发展部(DfID ),高等教育发展合作伙伴关系(DelPHE),纽约卡内基公司(资助号B 8606),福特基金会(资助号11000399),Google.Org(资助号191994),Sida(Grant No.54100029),MacArthur基金会(Grant No. 10-95915-000-INP)和英国文化协会支持。

The dynamics of adult neurogenesis in human hippocampus

Amadi O. Ihunwo*, Lackson H. Tembo, Charles Dzamalala   

  1. School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • Received:2016-11-18 Online:2016-12-31 Published:2016-12-31
  • Contact: Amadi O. Ihunwo, Ph.D., Amadi.Ihunwo@wits.ac.za.
  • Supported by:
    This work was supported by the Consortium for Advanced Research Training in Africa (CARTA). CARTA is jointly led by the African Population and Health Research Center (APHRC) and the University of the Witwatersrand and funded by the Wellcome Trust (UK) (Grant No. 087547/Z/08/Z), the Department for International Development (DfID) under the Development Partnerships in Higher Education (DelPHE), the Carnegie Corporation of New York (Grant No. B 8606), the Ford Foundation (Grant No. 11000399), Google.Org (Grant No. 191994), Sida (Grant No. 54100029), MacArthur Foundation (Grant No. 10-95915-000-INP) and British Council.

摘要:

成人神经发生现象现已被广泛接受,这种现象在人类中至少可分别独立发生在两个位置。它们分别是嗅觉系统和海马。在其它动物中,新生成的神经元已经直接或间接地产生显着性数量,并具有功能作用。然而,在这一过程在人类中的研究数据仍然不足,并且给人类理解其意义作用造成困难。文章探讨了人类成年海马神经发生的可用数据,并将之与动物实验数据进行了对比。

orcid: 0000-0003-1097-7424 (Amadi O. Ihunwo)

Abstract: The phenomenon of adult neurogenesis is now an accepted occurrence in mammals and also in humans. At least two discrete places house stem cells for generation of neurons in adult brain. Tese are olfactory system and the hippocampus. In animals, newly generated neurons have been directly or indirectly demonstrated to generate a signifcant amount of new neurons to have a functional role. However, the data in humans on the extent of this process is still scanty and such as difcult to comprehend its functional role in humans. Tis paper explores the available data on as extent of adult hippocampal neurogenesis in humans and makes comparison to animal data.

Key words: adult neurogenesis, neuron, neuronal stem cell, proliferation, differentiation, neuronal turn-over, hippocampus, human neurogenesis