中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (1): 13-18.doi: 10.4103/1673-5374.198965

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

血液微小RNA可作为出血性脑卒中的潜在诊断标志物

  

  • 收稿日期:2017-01-14 出版日期:2017-01-15 发布日期:2017-01-15

Blood microRNAs as potential diagnostic markers for hemorrhagic stroke

Bridget Martinez1,#, Philip V. Peplow2, *, #   

  1. 1. Department of Molecular and Cellular Biology, University of California, Merced, CA, USA; 2. Department of Anatomy, University of Otago, Dunedin, New Zealand
  • Received:2017-01-14 Online:2017-01-15 Published:2017-01-15
  • Contact: Philip V. Peplow, Ph.D., phil.peplow@otago.ac.nz.

摘要:

 

微小RNA是约22个核苷酸长度的小非编码RNA,参与基因表达调节,从而控制一系列生理和病理功能,例如发育、分化、凋亡和代谢。脑卒中患者的正确治疗依赖于缺血性和出血性脑卒中之间的精确和快速分化,在当前实践中可通过计算机断层成像或磁共振成像扫描进行。血液微小RNA已被证明是缺血性脑卒中的潜在诊断和预后生物标志物。一组微小RNA可以是区分出血性和缺血性脑卒中的非常有效的临床工具。在这篇综述文章中,我们证实血液微小RNA谱可以区分患者和实验动物模型中的出血性和缺血性卒中类型。并建议它们可以区分脑内和蛛网膜下腔出血性卒中。脑脊液中的微小RNA谱可能是蛛网膜下出血性脑卒中的有用诊断工具。减少或增加微小RNA水平在预防或治疗脑卒中时或许是必须要素。文章还表示脑内出血动物模型中体内施用miR-130a抑制剂或微小RNA模拟物(miR-367,miR-223)能够改善神经学结果。

 

 

Abstract:

Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinical tool in distinguishing between hemorrhagic and ischemic stroke. This review has shown that blood miRNA profile can distinguish hemorrhagic from ischemic stroke in patients and in experimental animal models. It also seems likely they can differentiate between intracerebral and subarachnoid hemorrhage stroke. The miRNA profile in cerebrospinal fluid could be a useful diagnostic tool for subarachnoid hemorrhagic stroke. Decreased or increased miRNA levels may be needed either as prevention or treatment of stroke. Administration in vivo of miR-130a inhibitor or miRNA mimic (miR-367, miR-223) in an intracerebral hemorrhage animal model improved neurological outcomes.

Key words: blood microRNAs, diagnostic biomarkers, hemorrhagic stroke, human patients, rat and mouse models