中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (1): 90-95.doi: 10.4103/1673-5374.198990

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

灯盏花素治疗脑外伤:能够抑制早期的炎症反应

  

  • 收稿日期:2016-11-26 出版日期:2017-01-15 发布日期:2017-01-15

Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression

 Ling Jiang, Yue Hu, Xiang He, Qiang Lv, Ting-hua Wang, Qing-jie Xia   

  1. Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • Received:2016-11-26 Online:2017-01-15 Published:2017-01-15
  • Contact: Qing-jie Xia, Ph.D., xiaqj2005@126.com.

摘要:

由短葶飞蓬中提取的灯盏花素已被广泛用于治疗脑卒中,但作用机制尚不完全明了。为此,实验以控制性脑皮质撞击左额叶区建立了创伤性脑损伤大鼠模型,然后立即在右侧脑室注射75μg灯盏花素进行治疗。6d后,损伤大鼠的神经行为功能显著改善,损伤皮质部位白细胞介素6mRNA表达及蛋白免疫反应明显降低。这些结果表明,灯盏花素能够改善创伤性脑损伤早期神经功能的作用与其抑制白细胞介素6的表达有关。

ORCID:0000-0001-7135-2925(Ling Jiang)

Abstract:

Breviscapine, extracted from the herb Erigeron breviscapus is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and injected 75 μg breviscapine via the right lateral ventricle. We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection. Meanwhile, interleukin-6 expression was markedly down-regulated following breviscapine treatment.Our results suggest that breviscapine is effective in promoting neurological behavior after traumatic brain injury and the underlying molecular mechanism may be associated with the suppression of IL-6.

Key words: nerve regeneration, breviscapine, traumatic brain injury, neuroprotective effect, interleukin-6, neural regeneration