中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (2): 173-180.doi: 10.4103/1673-5374.200793

• 综述:视神经损伤修复保护与再生 •    下一篇

基于干细胞的眼科治疗学

  

  • 收稿日期:2017-02-06 出版日期:2017-02-15 发布日期:2017-02-15
  • 基金资助:

    这项研究得到了美国马里兰州巴尔的摩Zanvyl和Isabelle Krieger基金的部分支持; ISF(1189/12,NGC)。

The promise of stem cell-based therapeutics in ophthalmology

Israel Aharony1, Shalom Michowiz1, 2, Nitza Goldenberg-Cohen1, 3   

  1. 1. The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 
    2. Department of Neurosurgery, Rabin Medical Center – Beilinson Hospital, Petach Tikva, Israel; 
    3. Department of Ophthalmology, Bnai Zion Medical Center, Haifa, Israel
  • Received:2017-02-06 Online:2017-02-15 Published:2017-02-15
  • Contact: Nitza Goldenberg-Cohen, M.D., ncohen1@gmail.com.
  • Supported by:

    This study was partially supported by the Zanvyl and Isabelle Krieger Fund, Baltimore, Maryland, USA; Israel Scientific Foundation, ISF (1189/12, NGC).

摘要:

 

与实施细胞治疗以保持和恢复视力相关的前景引发了研究人员对实施胚胎(ESC),成人和诱导多能干细胞(iPS)表征的极大研究兴趣。 可潜在使用的三个主要方向包括持续药物递送,免疫调节和分化成各种眼结构。 虽然所有三种类型的干细胞分化为上皮,神经,胶质和血管表型的能力已经达到了可以在培养中得到证实的程度,但对视力矫正治疗以及有效体内实施要求的定义仍然处于相当早的发育阶段。 在这篇文章中,我们概述一些视网膜急性损伤后和退行性疾病中试图拯救和再生角膜的临床前研究。

Abstract:

The promising role of cellular therapies in the preservation and restoration of visual function has prompted intensive efforts to characterize embryonic, adult, and induced pluripotent stem cells for regenerative purposes. Three main approaches to the use of stem cells have been described: sustained drug delivery, immunomodulation, and differentiation into various ocular structures. Studies of the differentiation capacity of all three types of stem cells into epithelial, neural, glial and vascular phenotypes have reached proof-of-concept in culture, but the correction of vision is still in the early developmental stages, and the requirements for effective in vivo implementation are still unclear. We present an overview of some of the preclinical findings on stem-cell rescue and regeneration of the cornea and retina in acute injury and degenerative disorders.

Key words: embryonic stem cells, adult stem cells, induced pluripotent stem cells, cornea, retina, neuroprotection, immunomodulation, tissue recovery, regeneration, acute ocular injury, degenerative retinal disorders