中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (2): 220-227.doi: 10.4103/1673-5374.200805
槲皮素预处理保护短暂性脑缺血海马CA1区锥体神经元
Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes
Bai Hui Chen1, Joon Ha Park2, JiHyeon Ahn2, JeongHwi Cho3, In Hye Kim3, Jae Chul Lee3, Moo-Ho Won3, Choong-Hyun Lee4, In Koo Hwang5, Jong-Dai Kim6, Il Jun Kang7, Jun Hwi Cho8, Bich Na Shin9, Yang Hee Kim10, Yun Lyul Lee9, Seung Min Park11
- 1 Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang Province, China;
2 Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, South Korea;
3 Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea;
4 Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, South Korea;
5 Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea;
6 Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon, South Korea;
7 Department of Food Science and Nutrition, Hallym University, Chuncheon, South Korea;
8 Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon, South Korea;
9 Department of Physiology, College of Medicine, and Institute of Neurodegeneration and Neuroregeneration, Hallym University, Chuncheon, South Korea;
10 Department of Surgery, School of Medicine, Kangwon National University, Chuncheon, South Korea;
11 Department of Emergency Medicine, Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, South Korea
摘要：
槲皮素主要用于预防神经退行性疾病和缺血性损害，但其神经保护机制尚不明了。实验对在建立5min的短暂性脑缺血沙鼠模型前，行槲皮素灌胃15d预处理。神经元核抗原免疫组化和Fluoro-Jade B组织荧光染色检测显示槲皮素预处理减轻了短暂性脑缺血沙鼠海马CA1区锥体神经元损伤；同时槲皮素预处理还使短暂性脑缺血沙鼠海马CA1区锥体神经元中内源性抗氧化酶铜锌超氧化物歧化酶、锰超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶活性明显升高。从而表明槲皮素预处理通过增加短暂性脑缺血后海马CA1区锥体神经元抗氧化酶活性，对该神经元起到保护作用。
ORCID:0000-0003-0504-5825(Yun Lyul Lee); 0000-0002-3594-8403(Seung Min Park)