中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (3): 354-357.doi: 10.4103/1673-5374.202919

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

NF-κBp50在星形胶质细胞介导的成体神经祖细胞自主和非细胞自主命运中的作用

  

  • 收稿日期:2017-02-14 出版日期:2017-03-15 发布日期:2017-03-15

Novel insights into the role of NF-κB p50 in astrocytemediated fate specification of adult neural progenitor cells

Valeria Bortolotto, Mariagrazia Grilli   

  1. Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy
  • Received:2017-02-14 Online:2017-03-15 Published:2017-03-15
  • Contact: Mariagrazia Grilli, M.D., mariagrazia.grilli@uniupo.it.

摘要:

文中实验表明,在缺少NF-κB p50的情况下,复杂的细胞自主和非细胞自主的变化可以影响成体神经祖细胞命运。文章研究还显示LCN-2是星形胶质细胞来源的信号,促进成体海马神经祖细胞的神经元命运及其活性,24p3R的下调的同时,大大减少在p50KO神经祖细胞的数量。 总而言之,越来越多的数据表明,NF-B信号调控成体海马神经发生及星形胶质细胞在神经发生中的关键作用。

ORCID:0000-0001-9165-5827(Mariagrazia Grilli)

Abstract:

Within the CNS nuclear factor-kappa B (NF-κB) transcription factors are involved in a wide range of functions both in homeostasis and in pathology. Over the years, our and other groups produced a vast array of information on the complex involvement of NF-κB proteins in different aspects of postnatal neurogenesis. In particular, several extracellular signals and membrane receptors have been identified as being able to affect neural progenitor cells (NPC) and their progeny via NF-κB activation. A crucial role in the regulation of neuronal fate specification in adult hippocampal NPC is played by the NF-κB p50 subunit. NF-κB p50KO mice display a remarkable reduction in adult hippocampal neurogenesis which correlates with a selective defect in hippocampal-dependent short-term memory. Moreover absence of NF-κB p50 can profoundly affect the in vitro proneurogenic response of adult hippocampal NPC (ahNPC) to several endogenous signals and drugs. Herein we briefly review the current knowledge on the pivotal role of NF-κB p50 in the regulation of adult hippocampal neurogenesis. In addition we discuss more recent data that further extend the relevance of NF-κB p50 to novel astroglia-derived signals which can influence neuronal specification of ahNPC and to astrocyte-NPC cross-talk.

Key words: adult neurogenesis, hippocampus, astrocyte, neural progenitor cell, NGAL/LCN-2, conditioned medium, 24p3R