中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (3): 385-388.doi: 10.4103/1673-5374.202933

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

建立人脊髓损伤生物标志物的转化意义

  

  • 收稿日期:2017-02-28 出版日期:2017-03-15 发布日期:2017-03-15

The translational importance of establishing biomarkers of human spinal cord injury

Sanam Salimi Elizei1, Brian K. Kwon1, 2   

  1. 1 International Collaboration on Repair Discoveries (ICORD), University of British Columbia, BC, Canada; 2 Vancouver Spine Surgery Institute, Department of Orthopaedics, University of British Columbia, BC, Canada
  • Received:2017-02-28 Online:2017-03-15 Published:2017-03-15
  • Contact: Brian K. Kwon, M.D., Ph.D., FRCSC, brian.kwon@ubc.ca.

摘要:

脊髓损伤生物标志物的确定需要得到大规模研究的验证,许多与其他新型治疗方法相同,在这方面,在这个特定领域的工作将遭遇难以招募足够数量患者的困境。 然而,由于临床试验中需要评价新疗法对脊髓损伤患者的疗效,新的标志物的开发是及其紧迫的。文章认为生物标志物具有促进新疗法验证的潜力,并且在脊髓损伤的转化研究中具有关键作用。本文对脊髓损伤后24小时内50例急性脊髓损伤患者:32例颈部脊髓损伤和18例胸部脊髓损伤,对与颈部和胸部脊髓损伤损伤严重程度和预测神经功能恢复的程度相关的脑脊液中生物标志物进行了研究,包括IL-6,IL-8,MCP-1,tau,S100b和GFAP。其还试图招募更大样本量的患者,以确定这些生物标志物是否可以预测神经功能恢复。

ORCID:0000-0002-5089-8280(Brian K. Kwon)

Abstract:

Our current dependence upon the clinical assessment of neurologic impairment renders many acute SCI patients ineligible for trials because they are not examinable. Furthermore, the difficulty in predicting neurologic recovery based on the early clinical assessment forces investigators to recruit large cohorts to have sufficient power. Biomarkers that objectively classify injury severity and better predict neurologic outcome would be valuable tools for translational research. As such, the objective of the present review was to describe some of the translational challenges in acute spinal cord injury research and examine the potential utility of neurochemical biomarkers found within cerebrospinal fluid and blood. We focus on published efforts to establish biological markers for accurately classifying injury severity and precisely predict neurological outcome.

Key words: spinal cord injury, biomarkers, cerebrospinal fluid, injury severity, neurological recovery