中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (4): 549-557.doi: 10.4103/1673-5374.205084

• 综述:退行性病与再生 • 上一篇    下一篇

神经营养因子和阿尔茨海默病及帕金森病:对发病机制和治疗的意义

  

  • 收稿日期:2017-03-19 出版日期:2017-04-15 发布日期:2017-04-15
  • 基金资助:

    此研究由巴西机构:巴西国家科学技术发展委员会(CNPq)、CAPES、FAPERGS、FAPESC、FINEP(科学技术研究院)和INCT等共同赞助

 Neurotrophic factors in Alzheimer’s and Parkinson’s diseases: implications for pathogenesis and therapy

Tuane Bazanella Sampaio1, 2, Anne Suely Savall2, Maria Eduarda Ziani Gutierrez2, Simone Pinton2   

  1. 1 Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; 2 Universidade Federal do Pampa - Campus Uruguaiana, Uruguaiana, RS, Brazil
  • Received:2017-03-19 Online:2017-04-15 Published:2017-04-15
  • Contact: Simone Pinton, Ph.D.,sipinton@gmail.com.
  • Supported by:

    Work in the author’s laboratories is supported by the Brazilian agencies: Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Programa de Apoio aos Núcleos de Excelência (PRONEX), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Fundação de Apoio à Pesquisa do Estado de Santa Catarina (FAPESC), FINEP (Financiadora de Estudos e Projetos) and INCT (Instituto Nacional de Ciência e Tecnologia).

摘要:

神经营养因子的分泌蛋白必需包含有神经和非神经组织多种功能,其能调解发育、生存以及中枢和周围神经系统的维护。因此,神经营养因子在神经退行性疾病条件下已得到了广泛研究,因为这些因素的改变在成年神经发生中有共同的特点。阿尔茨海默病(AD)和帕金森病(PD)通过特异性改变神经营养因子调节,而这似乎是神经元变性的关键。事实上,神经营养因子,在退变过程中可以防止细胞死亡,同时增强神经元的生长和功能。文章讨论了关于神经营养因子支持存活,增殖和某些神经元的成熟,以及其作为AD和PD新治疗策略假定使用的发现。

ORCID:0000-0001-6630-7329(Simone Pinton)

Abstract:

Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer’s disease and Parkinson’s disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer’s disease and Parkinson’s disease as well as their putative application as new therapeutic approach for these diseases management.

Key words: BDNF, CDNF, GDNF, NGF, neurodegenerative diseases, treatment