中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (5): 677-686.doi: 10.4103/1673-5374.206636

• 综述:神经损伤修复保护与再生 •    下一篇

电和闪电损伤造成的神经和神经心理后果:评论和因果关系理论

  

  • 收稿日期:2017-04-24 出版日期:2017-05-15 发布日期:2017-05-15

Neurological and neuropsychological consequences of electrical and lightning shock: review and theories of causation

Christopher J. Andrews1, Andrew D. Reisner2   

  1. 1 Faculty of Medicine-The University of Queensland, Herston, Australia; Lightning and Electrical Injuries, Mt Ommaney Family Practice, Mt Ommaney, Brisbane, Australia; 2 Forensic Diagnostic Center of District Nine, Cambridge, OH, USA
  • Received:2017-04-24 Online:2017-05-15 Published:2017-05-15
  • Contact: Christopher J. Andrews, Ph.D., chris.a@pobox.com.

摘要:

 

来自闪电和电击伤的伤害涉及身体的多个系统,然而神经系统症状却被广泛报道。并此类损伤还涉及到神经心理综合征失能。本文提出了神经和神经心理症状的综合评论。

这些损伤因果关系的部分理论已经得到进一步研究,然而没有令人信服的解释以及延迟发病症状和神经心理综合征的起源。现有的已提出的一种理论满足这两个约束的因果关系,这一理论表明循环激素,如皮质醇,一氧化氮,以及来自谷氨酸能过度刺激的氧化自由基,作用于远离包括海马损伤路径的组织。本篇综述为探索治疗选择的研究途径提供了新方向及道路。

ORCID:0000-0001-7216-9866(Christopher J. Andrews)

Abstract:

Injuries from lightning and electrical injuries involve multiple systems of the body, however neurological symptoms are very widely reported. A disabling neuropsychological syndrome is also noted. This paper presents a comprehensive review of neurological and neuropsychological symptoms. Partial theories of causation for these injuries have been advanced, however, there is no convincing explanation for both delay in onset of symptoms and also the genesis of the neuropsychological syndrome. A theory of causation is proposed which satisfies both these constraints. This theory suggests circulating hormones such as cortisol, together with nitric oxide and oxidant free radicals from glutamatergic hyper-stimulation, act on tissues remote from the injury path including the hippocampus. This theory opens a research path to explore treatment options.

Key words: electrical injury;, lightning injury, neurology, neuropsychology, neuropsychiatry, injury, trauma