中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (6): 875-880.doi: 10.4103/1673-5374.208542

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

姜黄提取物对老化过程引起的突触变化及神经保护作用

  

  • 收稿日期:2017-06-09 出版日期:2017-06-15 发布日期:2017-06-15
  • 基金资助:

    本研究得到了VIEP-BUAP(FLAG-2017),ProDES(CA-BUAP-120)和墨西哥国家科学技术委员会的赞助支持(No. 252808)

Curcuma longa L. extract improves the cortical neural connectivity during the aging process

Gonzalo Flores   

  1. Laboratorio de Neuropsiquiatría, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México
  • Received:2017-06-09 Online:2017-06-15 Published:2017-06-15
  • Contact: Gonzalo Flores, Ph.D., gonzaloflores56@gmail.com or gonzalo.flores@correo.buap.mx.
  • Supported by:

    This study was supported by grants from the VIEP-BUAP grant (No. FLAG-2017), ProDES (CA-BUAP-120) and CONACYT grant (No. 252808) to GF.

摘要:

姜黄或姜黄是具有抗炎、抗氧化和抗凋亡药理性质的天然产物。它可用于控制老化过程,包括氧化应激、炎症和细胞凋亡。老化是一种生理过程,影响更高水平的皮质和认知功能,降低学习和记忆能力,造成有限的判断力和情绪控制以及社会行为缺陷。此外,老化是出现在脑血管疾病、糖尿病和高血压等几种疾病的主要危险因素。在大脑水平中,老化过程通过减少树突状心轴以及前额叶皮层(PFC),海马和基底外侧amydala(BLA)的锥体神经元中的树突棘数量来改变突触相互通信,从而减少这些地区的大小。本研究回顾了老化过程引起的突触变化以及姜黄具有抗炎、抗氧化和抗凋亡作用的神经保护作用。

ORCID:0000-0002-4100-2104(Gonzalo Flores)

Abstract:

Turmeric or Curcuma is a natural product that has anti-inflammatory, antioxidant and anti-apoptotic pharmacological properties. It can be used in the control of the aging process that involves oxidative stress, inflammation, and apoptosis. Aging is a physiological process that affects higher cortical and cognitive functions with a reduction in learning and memory, limited judgment and deficits in emotional control and social behavior. Moreover, aging is a major risk factor for the appearance of several disorders such as cerebrovascular disease, diabetes mellitus, and hypertension. At the brain level, the aging process alters the synaptic intercommunication by a reduction in the dendritic arbor as well as the number of the dendritic spine in the pyramidal neurons of the prefrontal cortex, hippocampus and basolateral amygdala, consequently reducing the size of these regions. The present review discusses the synaptic changes caused by the aging process and the neuroprotective role the Curcuma has through its anti-inflammatory, antioxidant and anti-apoptotic actions.

Key words: Curcuma, prefrontal cortex, hippocampus, amygdala, dendrites, aging