中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (7): 1024-1027.doi: 10.4103/1673-5374.211173

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

BDNF前肽:一种新型突触调节剂

  

  • 收稿日期:2017-07-05 出版日期:2017-07-15 发布日期:2017-07-15
  • 基金资助:

    此项工作得到了日本教育部、文化部、体育部、科技部优先领域(阐明大脑神经网络功能)科学研究补助金--KAKENHI科学研究补助金(17K07073和22500305)、 日本科技厅以及科技进化核心研究的赞助与支持。

BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing

Toshiyuki Mizui1, 3, Koji Ohira2, Masami Kojima1, 3, 4   

  1. 1 Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka, Japan; 2 Laboratory of Nutritional Brain Science, Department of Food Science and Nutrition, Mukogawa Women’s University, Hyogo, Japan; 3 Core Research for Evolutional Science and Technology (CREST), Science and Technology Agency (JST), Kawaguchi, Japan; 4 Graduate School of Frontier Bioscience, Osaka University, Suita, Japan
  • Received:2017-07-05 Online:2017-07-15 Published:2017-07-15
  • Contact: Masami Kojima, Ph.D., m-kojima@aist.go.jp.
  • Supported by:

    This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (Elucidation of neural network function in the brain) from the Ministry of Education, Culture, Sports, Science and Technology of Japan: KAKENHI Grant-in-Aid for Scientific Research (17K07073 and 22500305) (MK); Japan Science and Technology Agency; and Core Research for Evolutional Science and Technology (MK).

摘要:

脑源性神经营养因子(BDNF)作为一种生长激素,可以控制神经系统中的复杂生理过程。本文简要回顾了BDNF的作用,并着重于通过proBDNF前体的蛋白水解加工产生的新型生物活性BDNF前肽。 有趣的是,前肽促进海马长时程抑制,而BDNF增强了突触传递长时程增强。该领域的研究可以进一步加深人们对BDNF和相关蛋白质的神经生物学和神经病理学改变的认识。

ORCID:0000-0001-7769-9604(Masami Kojima)

Abstract:

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which is well-known neurotrophic factor in brain, has a potential ability to facilitate hippocampal long-term depression. Furthermore, a BDNF polymorphism Val66Met, which substitute valine into methionine at 66 amino acid, impacted the biological activity of the BDNF pro-peptide. We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.

Key words: BDNF, growth factor, neural stem cells, ischemia, peptide