中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (7): 1028-1035.doi: 10.4103/1673-5374.211174

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

糖皮质激素对神经发生的影响

  

  • 收稿日期:2017-07-07 出版日期:2017-07-15 发布日期:2017-07-15
  • 基金资助:

    此项研究得到了武田科学基金会、科学研究资助款(C)(JSPS KAKENHI JP16K06996)和日本教育部、文化部、体育部、科学技术部JSPS KAKENHI(赞助号17J04183)的赞助支持。

Impact of glucocorticoid on neurogenesis

Haruki Odaka1, 2, Naoki Adachi3, 4, Tadahiro Numakawa2, 4   

  1. 1 Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan; 2 Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan; 3 Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan; 4 Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan
  • Received:2017-07-07 Online:2017-07-15 Published:2017-07-15
  • Contact: Tadahiro Numakawa, Ph.D., numakawa.yyrmk@gmail.com.
  • Supported by:

    This study was supported by grants from by Takeda Science Foundation (TN, NA), and from the Grant-in-Aid for Scientific Research(C) (JSPS KAKENHI JP16K06996) (to TN) and JSPS KAKENHI Grant Number 17J04183 (to HO) in the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

摘要:

神经发生与脑部疾病密切联系,且可能有助于脑损伤修复。另一方面,研究已经证明糖皮质激素可影响胚胎和成年神经发生。通过细胞内信号通路如PI3K/Akt,Hedgehog和Wnt通路,神经干/祖细胞(NSPCs)的增殖/分化受糖皮质激素的影响。文章综述了关于糖皮质激素诱导的NSPC和相关细胞内信号分子的行为变化的研究,这些变化可内源性神经发生和细胞移植后大脑中NSPC的命运。

Abstract:

Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to brain diseases, including mental disorders and neurodevelopmental disease. Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors. Moreover, proliferation/differentiation of the neural stem/progenitor cells (NSPCs) is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase (PI3K)/Akt, hedgehog, and Wnt. Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms; this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases.

Key words: neural progenitor cells, glucocorticoids, neurogenesis, intracellular signaling pathways