中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (9): 1381-1389.doi: 10.4103/1673-5374.215240

• 综述:退行性病与再生 •    下一篇

红细胞生成素对神经退变和缺血性疾病的神经保护作用:EpoR的功效

  

  • 收稿日期:2017-08-26 出版日期:2017-09-15 发布日期:2017-09-15

Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor

Carolina Castillo Hernández1, 2, Carlos Felipe Burgos1, Angela Hidalgo Gajardo2, Tiare Silva-Grecchi1, Javiera Gavilan1, Jorge Roberto Toledo2, Jorge Fuentealba1   

  1. 1 Laboratory of Screening of Neuroactive Compounds, Department of Physiology, School of Biological Sciences, University of Concepción,Concepción, Chile
    2 Laboratory of Biotechnology and Biopharmaceutical, Department of Pathophysiology, School of Biological Sciences, University of Concepción,Concepción, Chile
  • Received:2017-08-26 Online:2017-09-15 Published:2017-09-15
  • Contact: Jorge Fuentealba,jorgefuentealba@udec.cl.
  • Supported by:

    This work was supported by the Innova Proyect, No. 13IDL218688, Fondecyt Proyect, No. 1130747, 1161078, PhD CONICYT Grant,No. 21130386.

摘要:

 

 

 

Abstract:

Erythropoietin (Epo) is a fundamental hormone in the egulation of hematopoiesis, and other secondary roles mediated by the binding of the hormone to its specific receptor (EpoR), which leads to an activation of key signaling pathways that induce an increase in cell differentiation, apoptosis control and neuroprotection.It has been suggested that their function depends on final conformation of glycosylations, related with affinity to the receptor and its half-life. The presence of EpoR has been reported in different tissues including central nervous system, where it has been demonstrated to exert a neuroprotective function against oxidative stress onditions, such as ischemic injury and neurodegenerative diseases. There is also evidence of an increase in EpoR expression in brain cell lysates of Alzheimer’s patients with respect to healthy patients. These results are related with extensive in vitro experimental data of neuroprotection obtained from cell lines, primary cell cultures and hippocampal slices. Additionally, this data is correlated with in vivo experiments (water maze test) in mouse models of Alzheimer’s disease where Epo treatment improved cognitive function. These studies support the idea that receptor activation induces a neuroprotective effect in neurodegenerative disorders including dementias, and especially Alzheimer’s disease. Taken together, available evidence suggests that Epo appears to be a central element for EpoR activation and neuroprotective properties in the central nervous system. In this review, we will describe the mechanisms associated with neuroprotection and its relation with the activation of EpoR in order with identify new targets to develop pharmacological strategies.

Key words: erythropoietin, erythropoietin receptor, neuroprotection, anti-apoptosis, Alzheimer’s diseas