中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (10): 1575-1585.doi: 10.4103/1673-5374.217320

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

在围产期脑损伤的背景下接受少突胶质细胞多样性

  

  • 收稿日期:2017-09-12 出版日期:2017-10-15 发布日期:2017-10-15

Embracing oligodendrocyte diversity in the context of perinatal injury

Jessie Newville1, Lauren L. Jantzie1, 2, Lee Anna Cunningham1   

  1. 1 Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    2 Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
  • Received:2017-09-12 Online:2017-10-15 Published:2017-10-15
  • Contact: Lee Anna Cunningham, Ph.D.,leeanna@salud.unm.edu.

摘要:

orcid:0000-0003-0294-5262(Lee Anna Cunningham)

Abstract:

Emerging evidence is fueling a new appreciation of oligodendrocyte diversity that is overturning the traditional view that oligodendrocytes are a homogenous cell population. Oligodendrocytes of distinct origins, maturational stages, and regional locations may differ in their functional capacity or susceptibility to injury. One of the most unique qualities of the oligodendrocyte is its ability to produce myelin. Myelin abnormalities have been ascribed to a remarkable array of perinatal brain injuries, with concomitant oligodendrocyte dysregulation. Within this review, we discuss new insights into the diversity of the oligodendrocyte lineage and highlight their relevance in paradigms of perinatal brain injury. Future therapeutic development will be informed by comprehensive knowledge of oligodendrocyte pathophysiology that considers the particular facets of heterogeneity that this lineage exhibits.

Key words:  oligodendrogenesis , oligodendrocyte progenitor cell , myelination , central nervous system development , ontogenetic origin , white matter , white matter injury , preterm birth , glia , macroglia