中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (11): 1762-1764.doi: 10.4103/1673-5374.219026

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

IRF2BP2:中风恢复的先天免疫反应的新玩家

  

  • 收稿日期:2017-09-30 出版日期:2017-11-15 发布日期:2017-11-15

Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery

Hsiao-Huei Chen1, Alexandre F. R. Stewart2   

  1. 1 Ottawa Hospital Research Institute, Ottawa, Canada
    2 University of Ottawa Heart Institute, Ottawa, Canada
  • Received:2017-09-30 Online:2017-11-15 Published:2017-11-15
  • Contact: Hsiao-Huei Chen, Ph.D.,hchen@uottawa.ca.
  • Supported by:

    This study was supported by a grant from the Heart and Stroke Foundation of Canada (HHC, AFRS), a grant from the Natural Science & Engineering Research Council of Canada (HHC, AFRS), a Mid-Career Investigator Award from the Heart and Stroke Foundation of Ontario, Canada (HHC).

摘要:

orcid:0000-0003-2914-6057(Hsiao-Huei Chen)

Abstract:

Ischemic brain injury triggers an inflammatory response. This response is necessary to clear damaged brain tissue but can also exacerbate brain injury. Microglia are the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function, pruning unused synapses between neurons. However, microglia become activated to an inflammatory phenotype upon brain injury. Interferon regulatory factors modulate microglial activation and their production of inflammatory cytokines. This review briefly discusses recent findings pertaining to these regulatory mechanisms in the context of stroke recovery.

Key words: interferon regulatory factors, interferon beta, microglia, interferon regulatory factor 2 binding protein 2, stroke, inflammation, synaptic pruning, anxiety