中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (11): 1786-1790.doi: 10.4103/1673-5374.219029

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

用于治疗脊髓损伤的电纺纤维支架的设计标准

  

  • 收稿日期:2017-10-25 出版日期:2017-11-15 发布日期:2017-11-15

Design and criteria of electrospun fibrous scaffolds for the treatment of spinal cord injury

Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Franca Ferrari   

  1. Department of Drug Sciences, University of Pavia, Viale Taramelli, Pavia, Italy
  • Received:2017-10-25 Online:2017-11-15 Published:2017-11-15
  • Contact: Silvia Rossi,silvia.rossi@unipv.it.

摘要:

orcid:0000-0001-9511-3857(Silvia Rossi)

Abstract:

 The complex pathophysiology of spinal cord injury may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. Many efforts have been performed to design and develop suitable scaffolds for spinal cord regeneration, keeping in mind that the reconstruction of a pro-regenerative environment is the key challenge for an effective neurogenesis. The aim of this review is to outline the main features of an ideal scaffold, based on biomaterials, produced by the electrospinning technique and intended for the spinal cord regeneration. An overview of the polymers more investigated in the production of neural fibrous scaffolds is also provided.

Key words: spinal cord injury, biomaterials, electrospun fibers, conductive scaffolds, morphological properties, biodegradability