中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (12): 1939-1944.doi: 10.4103/1673-5374.221146

• 综述:退行性病与再生 • 上一篇    下一篇

少突胶质细胞和胞外多糖细胞祖细胞对多发性硬化症中枢神经系统修复的贡献 - 髓鞘再生治疗策略的观点

  

  • 收稿日期:2017-11-22 出版日期:2017-12-15 发布日期:2017-12-15

The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies

Adriana Octaviana Dulamea   

  1. Department of Neurology, Fundeni Clinical Institute, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • Received:2017-11-22 Online:2017-12-15 Published:2017-12-15
  • Contact: Adriana Octaviana Dulamea,M.D.,adrianadulamea@gmail.com.

摘要:

orcid:0000-0002-5056-0191(Adriana Octaviana Dulamea)

Abstract:

  Oligodencrocytes (OLs) are the main glial cells of the central nervous system involved in myelination of axons. In multiple sclerosis (MS), there is an imbalance between demyelination and remyelination processes, the last one performed by oligodendrocyte progenitor cells (OPCs) and OLs, resulting into a permanent demyelination, axonal damage and neuronal loss. In MS lesions, astrocytes and microglias play an important part in permeabilization of blood-brain barrier and initiation of OPCs proliferation. Migration and differentiation of OPCs are influenced by various factors and the process is finalized by insufficient acummulation of OLs into the MS lesion. In relation to all these processes, the author will discuss the potential targets for remyelination strategies

Key words: multiple sclerosis, oligodencrocytes, oligodendrocyte progenitor cells, demyelination, remyelination, semaphorin, basic helix-loop-helix transcription factor oligodendrocyte transcription factor 2, leucin-rich repeat and immunoglobulin-like-domain-containing nogo receptor-interacting protein 1, canonical Notch signaling, endocrine receptors